H
Henri Jean Garchon
Researcher at French Institute of Health and Medical Research
Publications - 14
Citations - 1698
Henri Jean Garchon is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Human leukocyte antigen & Genome-wide association study. The author has an hindex of 11, co-authored 14 publications receiving 1568 citations. Previous affiliations of Henri Jean Garchon include University of Paris & Versailles Saint-Quentin-en-Yvelines University.
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Journal ArticleDOI
Insulin-Dependent Diabetes Mellitus (IDDM) Is Associated with CTLA4 Polymorphisms in Multiple Ethnic Groups
Michele P. Marron,Leslie J. Raffel,Henri Jean Garchon,Chaim O. Jacob,Manuel Serrano-Ríos,María Teresa Martínez Larrad,Wei Ping Teng,Yongsoo Park,Zhi Xing Zhang,Darlene R. Goldstein,Yi Wen Tao,Geneviève Beaurain,Jean Francois Bach,Hong So Huang,De Fang Luo,Adina Zeidler,Jerome I. Rotter,Mark C. K. Yang,Tamara Modilevsky,Noel K. Maclaren,Jin-Xiong She +20 more
TL;DR: The results suggest that a true IDDM susceptibility locus (designated IDDM12) is located near CTLA4, and the overall evidence for transmission deviation of theCTLA4 A/G alleles is highly significant.
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A functional variant of SUMO4, a new I kappa B alpha modifier, is associated with type 1 diabetes.
Dehuang Guo,Manyu Li,Yan Zhang,Ping Yang,Sarah Eckenrode,Diane Hopkins,Weipeng Zheng,Sharad Purohit,Robert H. Podolsky,Andrew Muir,Jinzhao Wang,Zheng Dong,Todd M. Brusko,Mark A. Atkinson,Paolo Pozzilli,Adina Zeidler,Leslie J. Raffel,Chaim O. Jacob,Yongsoo Park,Manuel Serrano-Ríos,María Teresa Martínez Larrad,Zixin Zhang,Henri Jean Garchon,Jean Francois Bach,Jerome I. Rotter,Jin-Xiong She,Cong-Yi Wang +26 more
TL;DR: Evidence is reported for an association between T1D and multiple single-nucleotide polymorphisms in 197 kb of genomic DNA in the IDDM5 interval and a new gene (SUMO4), encoding small ubiquitin-like modifier 4 protein, is cloned in the interval, suggesting a new pathway that may be implicated in the pathogenesis of type 1 diabetes.
Journal ArticleDOI
Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.
Adrian Cortes,Sara L. Pulit,Paul Leo,J J Pointon,Philip Robinson,Michael H. Weisman,Michael Ward,Lianne S. Gensler,Xiaodong Zhou,Henri Jean Garchon,Gilles Chiocchia,Johannes C. Nossent,Johannes C. Nossent,Benedicte A. Lie,Øystein Førre,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,Kari Laiho,Linda A. Bradbury,Dirk Elewaut,Ruben Burgos-Vargas,Simon Stebbings,Louise Appleton,Claire Farrah,Jonathan Lau,Nigil Haroon,Juan Mulero,Francisco J. Blanco,Miguel A. Gonzalez-Gay,Carlos López-Larrea,Paul Bowness,Karl Gaffney,Hill Gaston,Dafna D. Gladman,Dafna D. Gladman,Proton Rahman,Walter P. Maksymowych,J. Bart A. Crusius,Irene E. van der Horst-Bruinsma,Raphael Valle-Oñate,Consuelo Romero-Sánchez,Inger Myrnes Hansen,Fernando Pimentel-Santos,Robert D. Inman,Javier Martin,Maxime Breban,B P Wordsworth,John D. Reveille,David M. Evans,David M. Evans,Paul I.W. de Bakker,Matthew A. Brown +52 more
TL;DR: In this article, the authors genotyped 7,264 MHC SNPs in 22,647 ankylosing spondylitis (AS) cases and controls of European descent.
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An IRF8-binding promoter variant and AIRE control CHRNA1 promiscuous expression in thymus
Matthieu Giraud,Richard Taubert,Claire Vandiedonck,Xiayi Ke,Matthieu Lévi-Strauss,Franco Pagani,Francisco E. Baralle,Bruno Eymard,Christine Tranchant,Philippe Gajdos,Angela Vincent,Nick Willcox,David Beeson,Bruno Kyewski,Henri Jean Garchon +14 more
TL;DR: A critical function of AIRE and the interferon signalling pathway is revealed in regulating quantitative expression of this auto-antigen in the thymus, suggesting that together they set the threshold for self-tolerance versus autoimmunity.
Journal ArticleDOI
Risk for myasthenia gravis maps to a (151) Pro→Ala change in TNIP1 and to human leukocyte antigen-B*08.
Peter K. Gregersen,Roman Kosoy,Annette Lee,Janine A. Lamb,Jon Sussman,David McKee,Kim R. Simpfendorfer,Ritva Pirskanen-Matell,Frederik Piehl,Qiang Pan-Hammarström,Jan J.G.M. Verschuuren,Maarten J. Titulaer,Erik H. Niks,Alexander Marx,Philipp Ströbel,Björn Tackenberg,Michael Pütz,Angelina H. Maniaol,Ahmed Elsais,Chantal M. E. Tallaksen,Hanne F. Harbo,Benedicte A. Lie,Soumya Raychaudhuri,Soumya Raychaudhuri,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Arthur Melms,Henri Jean Garchon,Nicholas Willcox,Lennart Hammarström,Michael F. Seldin +31 more
TL;DR: The objective of this study is to comprehensively define the genetic basis of early onset myasthenia gravis (EOMG).