K
Kari Laiho
Researcher at University of Tampere
Publications - 47
Citations - 1118
Kari Laiho is an academic researcher from University of Tampere. The author has contributed to research in topics: Rheumatoid arthritis & Arthritis. The author has an hindex of 17, co-authored 47 publications receiving 1014 citations.
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Journal ArticleDOI
Major histocompatibility complex associations of ankylosing spondylitis are complex and involve further epistasis with ERAP1.
Adrian Cortes,Sara L. Pulit,Paul Leo,J J Pointon,Philip Robinson,Michael H. Weisman,Michael Ward,Lianne S. Gensler,Xiaodong Zhou,Henri Jean Garchon,Gilles Chiocchia,Johannes C. Nossent,Johannes C. Nossent,Benedicte A. Lie,Øystein Førre,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,Kari Laiho,Linda A. Bradbury,Dirk Elewaut,Ruben Burgos-Vargas,Simon Stebbings,Louise Appleton,Claire Farrah,Jonathan Lau,Nigil Haroon,Juan Mulero,Francisco J. Blanco,Miguel A. Gonzalez-Gay,Carlos López-Larrea,Paul Bowness,Karl Gaffney,Hill Gaston,Dafna D. Gladman,Dafna D. Gladman,Proton Rahman,Walter P. Maksymowych,J. Bart A. Crusius,Irene E. van der Horst-Bruinsma,Raphael Valle-Oñate,Consuelo Romero-Sánchez,Inger Myrnes Hansen,Fernando Pimentel-Santos,Robert D. Inman,Javier Martin,Maxime Breban,B P Wordsworth,John D. Reveille,David M. Evans,David M. Evans,Paul I.W. de Bakker,Matthew A. Brown +52 more
TL;DR: In this article, the authors genotyped 7,264 MHC SNPs in 22,647 ankylosing spondylitis (AS) cases and controls of European descent.
Finnish HLA studies confirm the increased risk conferred by HLA-B27 homozygosity in ankylosing spondylitis
E. Jaakkola,I. Herzberg,Kari Laiho,M. Barnardo,J J Pointon,Markku J Kauppi,K. Kaarela,E. Tuomilehto-Wolf,Jaakko Tuomilehto,B P Wordsworth,Matthew A. Brown +10 more
TL;DR: HLA-DRB1 alleles may influence the age of symptom onset of ankylosing spondylitis and HLA-B27 homozygosity is associated with a moderately increased risk of anKYlosingSponylitis compared with HLA,B27 heterozygosity.
Journal ArticleDOI
Finnish HLA studies confirm the increased risk conferred by HLA-B27 homozygosity in ankylosing spondylitis
E. Jaakkola,I. Herzberg,Kari Laiho,M. Barnardo,J J Pointon,Markku J Kauppi,K. Kaarela,E. Tuomilehto-Wolf,Jaakko Tuomilehto,B P Wordsworth,Matthew A. Brown +10 more
TL;DR: In this article, the influence of HLA-B27 homozygosity and HLADRB1 alleles in the susceptibility to, and severity of, ankylosing spondylitis in a Finnish population was determined.
Journal ArticleDOI
ERAP2 is associated with ankylosing spondylitis in HLA-B27-positive and HLA-B27-negative patients
Philip Robinson,Mary-Ellen Costello,Paul Leo,Linda A. Bradbury,Kelly A. Hollis,Adrian Cortes,Seung-Hun Lee,Kyung Bin Joo,Seung Cheol Shim,Michael H. Weisman,Michael Ward,Xiaodong Zhou,Henri Jean Garchon,Gilles Chiocchia,Johannes C. Nossent,Johannes C. Nossent,Benedicte A. Lie,Øystein Førre,Jaakko Tuomilehto,Jaakko Tuomilehto,Jaakko Tuomilehto,Kari Laiho,Lei Jiang,Yu Liu,Xin Wu,Dirk Elewaut,Ruben Burgos-Vargas,Lianne S. Gensler,Simon Stebbings,Nigil Haroon,Juan Mulero,José Luis Fernández-Sueiro,Miguel A. Gonzalez-Gay,Carlos López-Larrea,Paul Bowness,Karl Gafney,J. S. H. Gaston,Dafna D. Gladman,Dafna D. Gladman,Proton Rahman,Walter P. Maksymowych,Huji Xu,Irene E. van der Horst-Bruinsma,C.T. Chou,C.T. Chou,Raphael Valle-Oñate,Maria Consuelo Romero-Sanchez,Inger Myrnes Hansen,Fernando Pimentel-Santos,Robert D. Inman,Javier Martin,Maxime Breban,David M. Evans,David M. Evans,John D. Reveille,Tae-Hwan Kim,B. Paul Wordsworth,Matthew A. Brown +57 more
Abstract: The association of endoplasmic reticulum aminopeptidase 2 (ERAP2) with ankylosing spondylitis (AS) was recently described in the large International Genetics of AS Consortium Immunochip study. Variants in ERAP2 have also been associated with inflammatory bowel disease, psoriasis, acute anterior uveitis and birdshot chorioretinopathy. Subsequent investigation demonstrated an association of ERAP2 with AS which was present when one conditioned on one of the two independent haplotypes of ERAP1 associated with AS or when HLA-B27-negative patients were analysed separately. These two analyses provide analogous evidence for the association of ERAP2 with AS in HLA-B27-negative cases because of the genetic interaction between HLA-B27 and the AS-associated ERAP1 variants in AS cases. ERAP1 and ERAP2 are located on chromosome 5q15 in the opposite orientation. The locus is challenging to analyse because of the strong linkage disequilibrium (LD) across the locus and the epistasis between ERAP1 and HLA-B alleles associated with AS. We therefore sought to investigate the association of ERAP2 with AS in HLA-B27-positive patients. This is of clinical importance because functional studies have demonstrated that the strongly AS-protective variant rs2248374 causes a functional ERAP2 protein knockout, because its G allele causes a loss of ERAP2 protein expression. There is also a variant of ERAP2 which changes its enzyme catalytic activity and specificity (rs2549782, K392A). Because this is in almost complete LD with rs2248374 (1000 Genomes D′=1.00, r2=0.90), it is almost never translated in vivo. Further, the very strong LD between these markers means that analysis of rs2549782 for association would yield results almost identical to the results for rs2248374 presented below. Therefore, it is of relevance to determine whether the association of ERAP2 with HLA-B27-negative disease is also found in HLA-B27-positive cases, since ERAP inhibition may offer a novel therapeutic for AS...
Journal ArticleDOI
Secondary amyloidosis has decreased in patients with inflammatory joint disease in finland
TL;DR: It is suggested that a change in medication towards more frequent use of cytostatic agents is the reason for the reduction in incidence of secondary amyloidosis.