H
Henrik E. Mei
Researcher at Leibniz Association
Publications - 77
Citations - 7451
Henrik E. Mei is an academic researcher from Leibniz Association. The author has contributed to research in topics: Mass cytometry & Immune system. The author has an hindex of 32, co-authored 70 publications receiving 5115 citations. Previous affiliations of Henrik E. Mei include Humboldt State University & Stanford University.
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Journal ArticleDOI
Long-lived autoreactive plasma cells drive persistent autoimmune inflammation
TL;DR: Findings show that long-lived plasma cells refractory to immunosuppressants and B-cell depletion therapies contribute to the maintenance of humoral memory and, in autoimmunity, to autoreactive memory, and appear to be a promising new therapeutic target.
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Depletion of autoreactive immunologic memory followed by autologous hematopoietic stem cell transplantation in patients with refractory SLE induces long-term remission through de novo generation of a juvenile and tolerant immune system.
Tobias Alexander,Andreas Thiel,Oliver Rosen,Gero Massenkeil,Arne Sattler,Siegfried Kohler,Henrik E. Mei,Hartmut Radtke,E Gromnica-Ihle,Gerd-Rüdiger Burmester,Renate Arnold,Andreas Radbruch,Falk Hiepe +12 more
TL;DR: These data are the first to demonstrate that both depletion of the autoreactive immunologic memory and a profound resetting of the adaptive immune system are required to reestablish self-tolerance in SLE.
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Generation of stable monoclonal antibody-producing B cell receptor-positive human memory B cells by genetic programming
Mark J. Kwakkenbos,Sean A. Diehl,Etsuko Yasuda,Arjen Q. Bakker,Caroline M. M. van Geelen,Michaël V. Lukens,Grada M. van Bleek,Myra N Widjojoatmodjo,Willy M. J. M. Bogers,Henrik E. Mei,Andreas Radbruch,Ferenc A. Scheeren,Hergen Spits,Tim Beaumont +13 more
TL;DR: This method provides a new tool to study B cell biology and signal transduction through antigen-specific B cell receptors and for the rapid generation of high-affinity human monoclonal antibodies.
Journal ArticleDOI
Memory B and memory plasma cells.
Taketoshi Yoshida,Henrik E. Mei,Thomas Dörner,Falk Hiepe,Andreas Radbruch,Simon Fillatreau,Bimba F. Hoyer +6 more
TL;DR: The current concepts of memory B cells, the signals involved in their maintenance, and their role in enhanced secondary reactions are reviewed, as well as their selective targeting will depend on a molecular understanding of their lifestyle.
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Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry.
Chotima Böttcher,Stephan Schlickeiser,Marjolein A. M. Sneeboer,Désirée Kunkel,Anniki Knop,Evdokia Paza,Pawel Fidzinski,Larissa Kraus,G. Snijders,René S. Kahn,Axel R. Schulz,Henrik E. Mei,Elly M. Hol,Elly M. Hol,Britta Siegmund,Rainer Glauben,Eike Jakob Spruth,Lot de Witte,Lot de Witte,Josef Priller +19 more
TL;DR: The phenotypic signature of hu MG was identified, which was distinct from peripheral myeloid cells but was comparable to fresh huMG, and microglia regional heterogeneity was identified.