M
Marjolein A. M. Sneeboer
Researcher at Utrecht University
Publications - 20
Citations - 1326
Marjolein A. M. Sneeboer is an academic researcher from Utrecht University. The author has contributed to research in topics: Microglia & Transcriptome. The author has an hindex of 10, co-authored 18 publications receiving 665 citations. Previous affiliations of Marjolein A. M. Sneeboer include Icahn School of Medicine at Mount Sinai & Royal Netherlands Academy of Arts and Sciences.
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Journal ArticleDOI
Microglia innately develop within cerebral organoids.
Paul R. Ormel,Renata Vieira de Sá,Emma J. van Bodegraven,Henk Karst,Oliver Harschnitz,Marjolein A. M. Sneeboer,Lill Eva Johansen,Roland van Dijk,Nicky Scheefhals,Amber Berdenis van Berlekom,Eduardo Ribes Martínez,Sandra Kling,Harold D. MacGillavry,Leonard H. van den Berg,René S. Kahn,Elly M. Hol,Elly M. Hol,Lot de Witte,R. Jeroen Pasterkamp +18 more
TL;DR: It is demonstrated that mature microglia-like cells are generated within their cerebral organoid model, providing new avenues for studying human micro glia in a three-dimensional brain environment.
Journal ArticleDOI
Human microglia regional heterogeneity and phenotypes determined by multiplexed single-cell mass cytometry.
Chotima Böttcher,Stephan Schlickeiser,Marjolein A. M. Sneeboer,Désirée Kunkel,Anniki Knop,Evdokia Paza,Pawel Fidzinski,Larissa Kraus,G. Snijders,René S. Kahn,Axel R. Schulz,Henrik E. Mei,Elly M. Hol,Elly M. Hol,Britta Siegmund,Rainer Glauben,Eike Jakob Spruth,Lot de Witte,Lot de Witte,Josef Priller +19 more
TL;DR: The phenotypic signature of hu MG was identified, which was distinct from peripheral myeloid cells but was comparable to fresh huMG, and microglia regional heterogeneity was identified.
Journal ArticleDOI
CSF-1 controls cerebellar microglia and is required for motor function and social interaction
Veronika Kana,Fiona Desland,Maria Casanova-Acebes,Pinar Ayata,Ana Badimon,Elisa M. Nabel,Kazuhiko Yamamuro,Marjolein A. M. Sneeboer,I-li Tan,Meghan E. Flanigan,Samuel A. Rose,Christie Chang,Andrew Leader,Hortense Le Bourhis,Eric S. Sweet,Navpreet Tung,Aleksandra Wroblewska,Yonit Lavin,Peter See,Alessia Baccarini,Florent Ginhoux,Violeta Chitu,E. Richard Stanley,Scott J. Russo,Zhenyu Yue,Brian D. Brown,Alexandra L. Joyner,Lotje de Witte,Lotje de Witte,Hirofumi Morishita,Anne Schaefer,Miriam Merad +31 more
TL;DR: Kana et al. show CSF-1 signaling is critical for cerebellar microglial transcriptional identity and homeostasis, and that altering the CSf-1–CSF- 1R axis leads to motor and behavioral defects.
Journal ArticleDOI
Fully defined human pluripotent stem cell-derived microglia and tri-culture system model C3 production in Alzheimer's disease.
Sudha R Guttikonda,Lisa Sikkema,Jason Tchieu,Nathalie Saurat,Ryan M. Walsh,Oliver Harschnitz,Gabriele Ciceri,Marjolein A. M. Sneeboer,Linas Mazutis,Manu Setty,Paul Zumbo,Doron Betel,Lot de Witte,Lot de Witte,Dana Pe'er,Lorenz Studer +15 more
TL;DR: In this paper, the authors developed a new approach to derive microglia from human pluripotent stem cells (hPSCs) and built a defined hPSC-derived tri-culture system containing pure populations of hPSCs-derived micro-glia, astrocytes, and neurons to dissect cellular cross-talk along the neuroinflammatory axis in vitro.
Journal ArticleDOI
Characterizing primary human microglia: A comparative study with myeloid subsets and culture models.
Jeroen Melief,Marjolein A. M. Sneeboer,Marjolein A. M. Sneeboer,M Litjens,M Litjens,P R Ormel,P R Ormel,S J M C Palmen,I Huitinga,René S. Kahn,Elly M. Hol,Elly M. Hol,Elly M. Hol,L D de Witte,L D de Witte +14 more
TL;DR: A large phenotypic discrepancy is defined between primary human microglia and currently used microglial cell models and cell lines, and it is shown that currently used cellular models only partly reflect the phenotype of primary humanmicroglia.