Hermann Josef Gröne

TL;DR: It is demonstrated that Dickkopf 3 (DKK3) is an agonist for canonical Wnt signaling in CKD and fosters chronic fibrosing inflammation of the tubulointerstitial compartment.

TL;DR: In this review, different issues of the LCM technique and the RNA amplification procedure for microarray analysis are discussed and an exemplary summary of results obtained from gene profiling of epithelial and stromal cells from human prostate tumors is presented, demonstrating the power of LCM-based molecular analysis.

TL;DR: These findings show that CREB is required for the efficient production of GHRH in hypothalamus, in addition to its previously reported role in pituitary GH production and somatotroph expansion.

TL;DR: Investigation of kidney biopsies of patients with renal failure revealed a typical histopathological appearance for hantavirus infections in all seven suspected HFRS cases and one case of unknown cause, allowing insight into the molecular epidemiology of HFRS-causing agents.

TL;DR: Data reveal an important role of this integrin subclass in leukocyte recruitment and development and maintenance of acute rejection; blockade of alpha(v) integrins may provide a new therapeutic strategy to attenuate acute allograft rejection.