H
Hermann Josef Gröne
Researcher at German Cancer Research Center
Publications - 357
Citations - 25145
Hermann Josef Gröne is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Kidney & Chemokine. The author has an hindex of 82, co-authored 346 publications receiving 23147 citations.
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Journal ArticleDOI
Differential expression of beta-chemokines MCP-1 and RANTES and their receptors CCR1, CCR2, CCR5 in acute rejection and chronic allograft nephropathy of human renal allografts.
TL;DR: The positive correlation between chemokines and chemokine receptors and infiltrating leukocytes during acute rejection, the lower but detectable expression of MCP-1, RANTES, CCR 1, C CR2 and CCR5 in CAN, and the differences in the quantity of expression point to a complex regulation of Chemokine expression in renal allografts.
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Influence of Native and Hypochlorite-Modified Low-Density Lipoprotein on Gene Expression in Human Proximal Tubular Epithelium
Stefan Porubsky,Holger Schmid,Mahnaz Bonrouhi,Matthias Kretzler,Ernst Malle,Peter J. Nelson,Hermann Josef Gröne +6 more
TL;DR: The demonstration of selective up-regulation of a subgroup of genes if proteinuria is accompanied by the presence of HOCl-modified (lipo)proteins support the potential pathophysiological role of the myeloperoxidase-H(2)O(2)-halide system and HOCl -LDL in renal disease.
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Identification of protein targets for mycophenolic acid acyl glucuronide in rat liver and colon tissue
Maria Shipkova,Hermann Beck,Antje Voland,Victor W. Armstrong,Hermann Josef Gröne,Michael Oellerich,Eberhard Wieland +6 more
TL;DR: This study shows for the first time the formation of adducts between tissue proteins and AcMPAG, which may contribute to a better understanding of the mechanisms responsible for the development of side effects during therapy with this drug.
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Inhibition of inducible nitric oxide synthase improves graft function and reduces tubulointerstitial injury in renal allograft rejection
Ingrid H. C. Vos,Ingrid H. C. Vos,Jaap A. Joles,Merel Schurink,Gisbert Weckbecker,Tomislav Stojanovic,Ton J. Rabelink,Hermann Josef Gröne +7 more
TL;DR: Adding the iNOS blockers iminoethyl-lysine or butylhexahydro-azepin-imine to cyclosporine-A improved graft function and reduced tubulointerstitial lesions in renal allografts.
Journal ArticleDOI
Immunodetection and quantification of vascular endothelial growth factor receptor-3 in human malignant tumor tissues
Hiroko Bando,Maten Brokelmann,Masakazu Toi,Kari Alitalo,Jonathan P. Sleeman,Bence Sipos,Hermann Josef Gröne,Herbert A. Weich +7 more
TL;DR: This assay provides a useful tool for the investigations of the expression levels of VEGFR‐3 in physiological and pathological processes, particular in cancer and in lymphangiogenesis‐related disease.