Hermann Josef Gröne

TL;DR: Mixed lymphocyte reaction revealed that the weaker alloreactivity was associated with a 85% lower cytotoxicity and a 50–80% lower cytokine release in Rhoh‐deficient T cells without an influence on the secretion itself, stressing the importance of Rhoh for the function of peripheral T cells.

TL;DR: A novel method to analyze the protein content of endosomes containing soluble antigens by flow cytometry is described, taking particular care to avoid unwanted clustering of individualendosomes, which can occur during centrifugation, as this severely affects the reliability of the flow cytometric analysis.

TL;DR: The data illustrate that ADPGK is part of a glucose sensing system in the ER modulating metabolism via regulation of N- and O-glycosylation, and indicates its role in T cell receptor activation-induced remodeling of energy metabolism.

TL;DR: A critical albeit differential role of T‐ cell lymphopenia in the susceptibility to organ‐specific autoimmune responses is confirmed and supported by the observation that adoptive T‐cell transfer corrected the TCR repertoire and improved EAE.