H
Hermann Josef Gröne
Researcher at German Cancer Research Center
Publications - 357
Citations - 25145
Hermann Josef Gröne is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Kidney & Chemokine. The author has an hindex of 82, co-authored 346 publications receiving 23147 citations.
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Journal ArticleDOI
Loss of ceramide synthase 3 causes lethal skin barrier disruption
Richard Jennemann,Mariona Rabionet,Karin Gorgas,Sharon Epstein,Alexander Dalpke,Ulrike Rothermel,Aline Bayerle,Franciscus van der Hoeven,Silke Imgrund,Joachim Kirsch,Walter Nickel,Klaus Willecke,Howard Riezman,Hermann Josef Gröne,Roger Sandhoff +14 more
TL;DR: This work has identified human and mouse ceramide synthase 3 (CerS3), among CerS1-6, to be exclusively required for the ULC-Cer synthesis in vitro and of mouse CerS3 in vivo.
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Viral Double-Stranded RNA Aggravates Lupus Nephritis through Toll-Like Receptor 3 on Glomerular Mesangial Cells and Antigen-Presenting Cells
Prashant S. Patole,Hermann Josef Gröne,Stephan Segerer,Raluca Ciubar,Emilia Belemezova,Anna Henger,Matthias Kretzler,Detlef Schlöndorff,Hans-Joachim Anders +8 more
TL;DR: It was concluded that viral dsRNA triggers disease activity of lupus nephritis by mechanisms that are different from those of bacterial DNA.
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Activation of toll-like receptor-9 induces progression of renal disease in MRL-Fas(lpr) mice
Hans-Joachim Anders,Volker Vielhauer,Vaclav Eis,Yvonne Linde,Matthias Kretzler,Guillermo Pérez de Lema,Frank Strutz,Stefan Bauer,Mark Rutz,Hermann Wagner,Hermann Josef Gröne,Detlef Schlöndorff +11 more
TL;DR: It is concluded that TLR9 activation triggers disease activity of systemic autoimmunity, for example, lupus nephritis, and that adaptive and innate immune mechanisms contribute to the CpG‐DNA‐induced progression of lupulonephritis.
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A chemokine receptor CCR-1 antagonist reduces renal fibrosis after unilateral ureter ligation.
Hans-Joachim Anders,Volker Vielhauer,Michael Frink,Yvonne Linde,Clemens D. Cohen,Simone Monika Blattner,Matthias Kretzler,Frank Strutz,Matthias Mack,Hermann Josef Gröne,James Onuffer,Richard Horuk,Peter J. Nelson,Detlef Schlöndorff +13 more
TL;DR: It is concluded that CCR1 blockade may represent a new therapeutic strategy for reducing cellular infiltration and renal fibrosis as major factors in the progression to end-stage renal failure.
Journal ArticleDOI
Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury
Felix Heymann,Catherine Meyer-Schwesinger,Emma E. Hamilton-Williams,Emma E. Hamilton-Williams,Linda Hammerich,Ulf Panzer,Sylvia Kaden,Susan E. Quaggin,Jürgen Floege,Hermann Josef Gröne,Christian Kurts +10 more
TL;DR: It is demonstrated that glomerular antigen-specific CTLs and Th cells can jointly induce renal immunopathology and identify kidney DCs as a mechanistic link between glomerulonephritis and the progression of kidney disease.