H
Hong Wang
Researcher at Kunming University of Science and Technology
Publications - 25
Citations - 885
Hong Wang is an academic researcher from Kunming University of Science and Technology. The author has contributed to research in topics: Cryopreservation & Sperm motility. The author has an hindex of 14, co-authored 25 publications receiving 676 citations. Previous affiliations of Hong Wang include Chinese Academy of Sciences & Kunming Institute of Zoology.
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Journal ArticleDOI
TALEN-Mediated Gene Mutagenesis in Rhesus and Cynomolgus Monkeys
Hailiang Liu,Yongchang Chen,Yuyu Niu,Kunshan Zhang,Yu Kang,Weihong Ge,Xiaojing Liu,Enfeng Zhao,Chencheng Wang,Shaoyun Lin,Bo Jing,Chenyang Si,Quan Lin,Quan Lin,Xiaoying Chen,Xiaoying Chen,Haijun Lin,Xiuqiong Pu,Yingying Wang,Binlian Qin,Fang Wang,Hong Wang,Wei Si,Jing Zhou,Tao Tan,Tianqing Li,Shaohui Ji,Zhigang Xue,Yuping Luo,Liming Cheng,Qi Zhou,Siguang Li,Yi E. Sun,Yi E. Sun,Weizhi Ji +34 more
TL;DR: It is concluded that TALEN-mediated mutagenesis can be an effective tool for genetic modeling of human disease in nonhuman primates.
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Dissecting primate early post-implantation development using long-term in vitro embryo culture
Yuyu Niu,Nianqin Sun,Chang Li,Ying Lei,Zhihao Huang,Jun Wu,Jun Wu,Chenyang Si,Xi Dai,Chuanyu Liu,Jingkuan Wei,Longqi Liu,Su Feng,Yu Kang,Wei Si,Hong Wang,E. Zhang,Lu Zhao,Ziwei Li,Xi Luo,Guizhong Cui,Guangdun Peng,Juan Carlos Izpisua Belmonte,Weizhi Ji,Weizhi Ji,Tao Tan +25 more
TL;DR: A human embryo in vitro culture protocol is modified that enables the development of cynomolgus monkey (long-tailed macaque) embryos to develop up to 20 days after fertilization and delineates the developmental trajectories of EPI, trophoblast, and primitive endoderm (PE) lineages.
Journal ArticleDOI
Early Parkinson's disease symptoms in α-synuclein transgenic monkeys
Yuyu Niu,Xiangyu Guo,Yongchang Chen,Chuan En Wang,Jinquan Gao,Weili Yang,Yu Kang,Wei Si,Hong Wang,Shang Hsun Yang,Shihua Li,Weizhi Ji,Xiao-Jiang Li +12 more
TL;DR: The transgenic α-syn monkeys demonstrate the specific early symptoms caused by mutantα-syn and provide insight into treatment of early PD.
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Chimeric contribution of human extended pluripotent stem cells to monkey embryos ex vivo
Tao Tan,Jun Wu,Chenyang Si,Shao-Xing Dai,Youyue Zhang,Nianqin Sun,E. Zhang,Honglian Shao,Wei Si,Pengpeng Yang,Hong Wang,Zhenzhen Chen,Ran Zhu,Yu Kang,Reyna Hernández-Benítez,Llanos Martinez Martinez,Estrella Nuñez Delicado,W. Travis Berggren,May Schwarz,Zongyong Ai,Tianqing Li,Hongkui Deng,Concepcion Rodriguez Esteban,Weizhi Ji,Yuyu Niu,Juan Carlos Izpisua Belmonte,Juan Carlos Izpisua Belmonte +26 more
TL;DR: In this paper, the chimeric competency of human extended pluripotent stem cells (hEPSCs) in cynomolgus monkey (Macaca fascicularis) embryos cultured ex vivo was investigated.
Journal ArticleDOI
CRISPR/Cas9-mediated Dax1 knockout in the monkey recapitulates human AHC-HH
Yu Kang,Bo Zheng,Bin Shen,Yongchang Chen,Lei Wang,Jianying Wang,Yuyu Niu,Yiqiang Cui,Jiankui Zhou,Hong Wang,Xuejiang Guo,Bian Hu,Qi Zhou,Jiahao Sha,Weizhi Ji,Xingxu Huang,Xingxu Huang +16 more
TL;DR: A male fetal monkey in which targeted genome editing using CRISPR/Cas9 produced Dax1-null mutations in most somatic tissues and in the gonads is described, revealing novel insight into the role of DAX1 in HH and providing proof-of-principle for the generation of monkey models of human disease via CRISpr/Cas 9-mediated gene targeting.