H
Huang-Chun Lien
Researcher at National Taiwan University
Publications - 73
Citations - 3595
Huang-Chun Lien is an academic researcher from National Taiwan University. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 29, co-authored 67 publications receiving 3106 citations. Previous affiliations of Huang-Chun Lien include University of Texas MD Anderson Cancer Center.
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Journal ArticleDOI
ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation
Jer Yen Yang,Cong S. Zong,Weiya Xia,Hirohito Yamaguchi,Qingqing Ding,Xiaoming Xie,Jingyu Lang,Chien-Chen Lai,Chun Ju Chang,Wei Chien Huang,Hsin Huang,Hsu-Ping Kuo,Hsu-Ping Kuo,Dung Fang Lee,Dung Fang Lee,Long Yuan Li,Long Yuan Li,Huang-Chun Lien,Xiaoyun Cheng,Xiaoyun Cheng,King-Jen Chang,Chwan-Deng Hsiao,Fuu Jen Tsai,Chang Hai Tsai,Chang Hai Tsai,Aysegul A. Sahin,William J. Muller,Gordon B. Mills,Dihua Yu,Gabriel N. Hortobagyi,Mien Chie Hung +30 more
TL;DR: This study elucidates a novel pathway in cell growth and tumorigenesis through negative regulation of FOXO3a by RAS–ERK and MDM2 and downregulates Forkhead box O 3a by directly interacting with and phosphorylating FOXO 3a at Ser 294, Ser 344 and Ser 425.
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Binding at and transactivation of the COX-2 promoter by nuclear tyrosine kinase receptor ErbB-2
Shao Chun Wang,Huang-Chun Lien,Weiya Xia,I. Fen Chen,Hui-Wen Lo,Zhiqin Wang,Mohamed Ali-Seyed,Dung Fang Lee,Dung Fang Lee,Geoffrey Bartholomeusz,Fu Ou-Yang,Dipak Giri,Mien Chie Hung +12 more
TL;DR: It is reported that ErbB-2 is also expressed in the nucleus in cultured cells as well as primary tumor tissues and the function of Erb B-2 as a transcriptional regulator is identified.
Journal Article
A novel role of metalloproteinase in cancer-mediated immunosuppression.
TL;DR: A new role of MMPs in tumor-mediated immunosuppression is suggested and a possible therapeutic potential for patients with cervical cancer is provided.
Journal ArticleDOI
Predominant Th2/Tc2 Polarity of Tumor-Infiltrating Lymphocytes in Human Cervical Cancer
TL;DR: It is demonstrated for the first time that TILs derived from human cervical cancer tissue consist mainly of Th2/Tc2 phenotypes, which strongly suggests important regulatory roles of IL-10 and TGF-β in cancer-mediated immunosuppression.
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Molecular signatures of metaplastic carcinoma of the breast by large-scale transcriptional profiling: identification of genes potentially related to epithelial–mesenchymal transition
Huang-Chun Lien,Y. H. Hsiao,Y. S. Lin,Y. T. Yao,Hsueh Fen Juan,Wen-Hung Kuo,Mien Chie Hung,King-Jen Chang,F. J. Hsieh +8 more
TL;DR: Genetic profiles of MCBs and their differences to those of ductal carcinoma of breasts (DCBs) are elucidated and the identification of SPARC and vimentin as poor prognostic factors reinforced the role of EMT in cancer progression.