Asian University

About: Asian University is a education organization based out in Bang Lamung, Thailand. It is known for research contribution in the topics: Dipole antenna & Characteristic impedance. The organization has 150 authors who have published 226 publications receiving 2494 citations.

ERK promotes tumorigenesis by inhibiting FOXO3a via MDM2-mediated degradation

Abstract: The RAS-ERK pathway is known to play a pivotal role in differentiation, proliferation and tumour progression. Here, we show that Erk downregulates Forkhead box O 3a (FOXO3a) by directly interacting with and phosphorylating FOXO3a at Ser 294, Ser 344 and Ser 425, which consequently promotes cell proliferation and tumorigenesis. The ERK-phosphorylated FOXO3a degrades via an MDM2-mediated ubiquitin-proteasome pathway. However, the non-phosphorylated FOXO3a mutant is resistant to the interaction and degradation by murine double minute 2 (MDM2), thereby resulting in a strong inhibition of cell proliferation and tumorigenicity. Taken together, our study elucidates a novel pathway in cell growth and tumorigenesis through negative regulation of FOXO3a by RAS-ERK and MDM2.

Effectiveness of Digital Marketing in the Challenging Age: An Empirical Study

Abstract: Marketers are faced with new challenges and opportunities within this digital age. Digital marketing is the utilization of electronic media by the marketers to promote the products or services into the market. The main objective of digital marketing is attracting customers and allowing them to interact with the brand through digital media. This article focuses on the importance of digital marketing for both marketers and consumers. We examine the effect of digital marketing on the firms' sales. Additionally the differences between traditional marketing and digital marketing in this paper are presented. This study has described various forms of digital marketing, effectiveness of it and the impact it has on firm's sales. The examined sample consists of one hundred fifty firms and fifty executives which have been randomly selected to prove the effectiveness of digital marketing. Collected data has been analyzed with the help of various statistical tools and techniques.

Energy-based Seismic Design of Structures using Yield Mechanism and Target Drift

Abstract: The use of energy as means to derive seismic design forces is discussed in this paper. The energy balance concept used in deriving seismic design forces for single-degree-of-freedom systems is exte...

Application of a Statistical Model Updating Approach on Phase I of the IASC-ASCE Structural Health Monitoring Benchmark Study

Abstract: This paper addresses the problem of structural health monitoring (SHM) and damage detection based on a statistical model updating methodology which utilizes the measured vibration responses of the ...