Ian Duguid

TL;DR: It is shown that sensory stimulation can produce bursts of spikes in single boutons at very high instantaneous firing frequencies (more than 700 Hz), and suggested that the relay from mossy fibre to granule cell can act in a ‘detonator’ fashion, such that a single presynaptic afferent may be sufficient to transmit the sensory message.

TL;DR: The characterization of several new variants of collybistin are reported, which are created by alternative splicing of exons encoding an N-terminal src homology 3 (SH3) domain and three alternate C termini (CB1, CB2, and CB3).

TL;DR: A newly identified form of inhibitory synaptic plasticity, termed depolarization-induced potentiation of inhibition, in rodents is reported, triggered by an elevation of Ca2+ in Purkinje cells and the subsequent retrograde activation of presynaptic NMDA receptors.

TL;DR: The results challenge the view that the climbing fiber conveys an all-or-none signal to the cerebellar cortex and help to link learning and timing theories of olivocerebellar function.

TL;DR: It is shown that missense, nonsense and frameshift mutations in SLC6A5 (ref. 8), encoding the presynaptic glycine transporter 2 (GlyT2), also cause hyperekplexia.