R
Robert J. Harvey
Researcher at University of the Sunshine Coast
Publications - 169
Citations - 11934
Robert J. Harvey is an academic researcher from University of the Sunshine Coast. The author has contributed to research in topics: Glycine receptor & Protein subunit. The author has an hindex of 56, co-authored 167 publications receiving 10926 citations. Previous affiliations of Robert J. Harvey include University of Hamburg & University of London.
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Journal ArticleDOI
Kinase activity is required for the toxic effects of mutant LRRK2/dardarin.
Elisa Greggio,Shushant Jain,Ann E. Kingsbury,Rina Bandopadhyay,Patrick A. Lewis,Alice Kaganovich,Marcel P. van der Brug,Alexandra Beilina,Jeff Blackinton,Kelly Jean Thomas,Rili Ahmad,David Miller,Sashi Kesavapany,Andrew B. Singleton,Andrew J. Lees,Robert J. Harvey,Kirsten Harvey,Mark R. Cookson +17 more
TL;DR: Manipulating activity by replacing the kinase domain with a 'kinase-dead' version blocks inclusion body formation and strongly delays cell death, predicting that kinase inhibitors will be useful therapeutic agents in patients with LRRK2 mutations and, perhaps, in sporadic PD.
Journal ArticleDOI
GlyR alpha3: an essential target for spinal PGE2-mediated inflammatory pain sensitization.
Robert J. Harvey,Ulrike B. Depner,Heinz Wässle,Seifollah Ahmadi,Cornelia Heindl,Heiko Reinold,Trevor G. Smart,Kirsten Harvey,Burkhard Schütz,Osama M. Abo-Salem,Andreas Zimmer,Pierrick Poisbeau,Hans Welzl,David P. Wolfer,Heinrich Betz,Hanns Ulrich Zeilhofer,Ulrike Müller +16 more
TL;DR: It is demonstrated that inhibition of a specific glycine receptor subtype (GlyR α3) by PGE2-induced receptor phosphorylation underlies central inflammatory pain sensitization and may provide a previously unrecognized molecular target in pain therapy.
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The mitochondrial protease HtrA2 is regulated by Parkinson's disease-associated kinase PINK1
Helene Plun-Favreau,Kristina Klupsch,Nicoleta Moisoi,Sonia Gandhi,Svend Kjaer,David Frith,Kirsten Harvey,Emma Deas,Robert J. Harvey,Neil Q. McDonald,Nicholas W. Wood,L. Miguel Martins,Julian Downward +12 more
TL;DR: It is suggested that PINK1-dependent phosphorylation of HtrA2 might modulate its proteolytic activity, thereby contributing to an increased resistance of cells to mitochondrial stress.
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Neuroligin 2 drives postsynaptic assembly at perisomatic inhibitory synapses through gephyrin and collybistin
Alexandros Poulopoulos,Gayane Aramuni,Guido Meyer,Tolga Soykan,Mrinalini Hoon,Theofilos Papadopoulos,Mingyue Zhang,Ingo Paarmann,Celine Fuchs,Kirsten Harvey,Peter Jedlicka,Stephan W. Schwarzacher,Heinrich Betz,Robert J. Harvey,Nils Brose,Nils Brose,Weiqi Zhang,Frederique Varoqueaux,Frederique Varoqueaux +18 more
TL;DR: Protein interactions of the synaptic adhesion molecule neuroligin 2 that drive postsynaptic differentiation at inhibitory synapses are identified and deleted in mice perturbs GABAergic and glycinergic synaptic transmission and leads to a loss of post Synaptic specializations specifically at perisomatic inhibitorysynaptic synapses.
Journal ArticleDOI
Mutations in α-Tubulin Cause Abnormal Neuronal Migration in Mice and Lissencephaly in Humans
David A. Keays,Guoling Tian,Karine Poirier,Guo-Jen Huang,Christian Siebold,James Cleak,Peter L. Oliver,Martin Fray,Robert J. Harvey,Zoltán Molnár,Maria Carmen Piñon,Neil Dear,William Valdar,Steve D.M. Brown,Kay E. Davies,J. Nicholas P. Rawlins,Nicholas J. Cowan,Patrick M. Nolan,Jamel Chelly,Jonathan Flint +19 more
TL;DR: The utility of ENU mutagenesis in the mouse as a means to discover the basis of human neurodevelopmental disorders is demonstrated and the causative mutation lies in the guanosine triphosphate (GTP) binding pocket of α-1 tubulin (Tuba1) and affects tubulin heterodimer formation.