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Ignacio J. General
Researcher at National Scientific and Technical Research Council
Publications - 35
Citations - 779
Ignacio J. General is an academic researcher from National Scientific and Technical Research Council. The author has contributed to research in topics: Quantum chromodynamics & Quark. The author has an hindex of 13, co-authored 34 publications receiving 697 citations. Previous affiliations of Ignacio J. General include Duquesne University & North Carolina State University.
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Journal ArticleDOI
Mechanisms of CFTR functional variants that impair regulated bicarbonate permeation and increase risk for pancreatitis but not for cystic fibrosis.
Jessica LaRusch,Jinsei Jung,Ignacio J. General,Michele D. Lewis,Hyun Woo Park,Randall E. Brand,Andres Gelrud,Michelle A. Anderson,Peter A. Banks,Darwin L. Conwell,Christopher Lawrence,Joseph Romagnuolo,John Baillie,Samer Alkaade,Gregory A. Cote,Timothy B. Gardner,Stephen T. Amann,Adam Slivka,Bimaljit S. Sandhu,Amy Aloe,Michelle L. Kienholz,Dhiraj Yadav,M. Michael Barmada,Ivet Bahar,Min Goo Lee,David C. Whitcomb +25 more
TL;DR: WNK1-SPAK pathway-activated increases in CFTR bicarbonate permeability are altered by CFTRBD variants through multiple mechanisms, and molecular dynamics simulations suggest physical restriction of the CFTR channel and altered dynamic channel regulation.
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ATPase subdomain IA is a mediator of interdomain allostery in Hsp70 molecular chaperones.
TL;DR: It is suggested that Hsp70 tends to adapt to co-chaperone recognition and activity via coevolving residues, whereas interdomain allostery, critical to chaperoning, is robustly enabled by conserved interactions.
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Frequent mutation of receptor protein tyrosine phosphatases provides a mechanism for STAT3 hyperactivation in head and neck cancer
Vivian Wai Yan Lui,Noah D. Peyser,Patrick Kwok Shing Ng,Jozef Hritz,Jozef Hritz,Yan Zeng,Yiling Lu,Hua Li,Lin Wang,Breean R. Gilbert,Ignacio J. General,Ivet Bahar,Zhenlin Ju,Zhenghe Wang,Kelsey P. Pendleton,Xiao Xiao,Yu Du,John K. Vries,Peter S. Hammerman,Levi A. Garraway,Gordon B. Mills,Daniel Johnson,Jennifer R. Grandis +22 more
TL;DR: It is demonstrated that receptor-like protein tyrosine phosphatases, encoded by PTPR genes, including PTPRT, are commonly mutated in HNSCC where PTPR mutations are associated with increased phosphorylation of STAT3 in tumors, providing a mechanistic basis for tumor-specific STAT3 hyperactivation in head and neck squamous cell carcinoma.
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A Note on the Standard State's Binding Free Energy.
TL;DR: This work presents a detailed and unifying explanation of the concepts involved and derive the necessary relations to convert a binding free energy from an arbitrary state to some given standard state.
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Coulomb gauge approach to qq̄g hybrid mesons
TL;DR: In this article, an effective Coulomb gauge Hamiltonian, Heff, is used to calculate the light (uūg), strange (ssg) and charmed (ccg) hybrid meson spectra, and a large-scale variational treatment predicts that the lightest hybrid has JPC=0++ and mass 2.1 GeV.