Journal ArticleDOI
Signatures of plasticity, metastasis, and immunosuppression in an atlas of human small cell lung cancer
Joseph M. Chan,Álvaro Quintanal-Villalonga,Vianne R. Gao,Vianne R. Gao,Yubin Xie,Yubin Xie,Viola Allaj,Ojasvi Chaudhary,Ignas Masilionis,Jacklynn V. Egger,Andrew Chow,Thomas Walle,Marissa Mattar,Dig Vijay Kumar Yarlagadda,James L. Wang,Fathema Uddin,Michael Offin,Metamia Ciampricotti,Besnik Qeriqi,Amber Bahr,Elisa de Stanchina,Umesh Bhanot,W. Victoria Lai,Matthew J. Bott,David R. Jones,Arvin Ruiz,Marina K. Baine,Yanyun Li,Natasha Rekhtman,John T. Poirier,Tal Nawy,Triparna Sen,Triparna Sen,Linas Mazutis,Travis J. Hollmann,Dana Pe'er,Charles M. Rudin,Charles M. Rudin +37 more
TLDR
In this article, the heterogeneity of small cell lung cancer (SCLC) is defined by differential expression of ASCL1, NEUROD1, and POU2F3.About:
This article is published in Cancer Cell.The article was published on 2021-11-08. It has received 111 citations till now. The article focuses on the topics: Adenocarcinoma & Metastasis.read more
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Clinical relevance of tumour-associated macrophages
TL;DR: The diversity of TAMs suggests different possibilities for exploiting particular subsets for therapeutic purposes; as a result, an arsenal of macrophage-targeted agents are currently being tested in the clinic and the inclusion of TAM data in precision oncology molecular tumour boards could become routine practice.
Journal ArticleDOI
Ferroptosis, necroptosis, and pyroptosis in the tumor microenvironment: perspectives for immunotherapy of SCLC.
TL;DR: In this paper , the authors summarize the roles of distinct ICD mechanisms on antitumor immunity and recent advances of ferroptosis-, necroptosis-and pyroptotic-inducing agents, and present perspectives on these cell death mechanisms in immunotherapy of small cell lung cancer.
Journal ArticleDOI
Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling
Joseph M. Chan,Samir Zaidi,Jillian R. Love,Jimmy L. Zhao,Manu Setty,Kristine M. Wadosky,Anuradha Gopalan,Zi-Ning Choo,Sitara Persad,Jungmin Choi,Justin R. LaClair,K. E. Lawrence,Ojasvi Chaudhary,Tianhao Xu,Ignas Masilionis,Irina Linkov,Shangqian Wang,Cindy Lee,Afsar Barlas,Michael J. Morris,Linas Mazutis,Ronan Chaligne,Yu Chen,David W. Goodrich,Wouter R. Karthaus,Dana Pe'er,Charles L. Sawyers +26 more
TL;DR: It is found that plasticity initiates in an epithelial population defined by mixed luminal-basal phenotype and that it depends on elevated JAK and FGFR activity.
Journal ArticleDOI
The translational challenges of precision oncology.
Oriol Pich,Christopher Bailey,Thomas B.K. Watkins,S. Zaccaria,Mariam Jamal-Hanjani,Charles Swanton +5 more
TL;DR: The translational challenges in the field of precision oncology are in part related to the biological complexity and diversity of this disease as discussed by the authors , and they have been further supported by large sequencing efforts and discoveries that further supported this notion.
Journal ArticleDOI
Targeting LSD1 rescues MHC class I antigen presentation and overcomes PD-L1 blockade resistance in small cell lung cancer.
E. Nguyen,Hirokazu Taniguchi,Joseph M. Chan,Yingqian Zhan,Xiaoping Chen,Juan Jan Qiu,Elisa de Stanchina,Viola Allaj,Nisargbhai S. Shah,Fathema Uddin,P. Manoj,Michael Liu,Sheng F. Cai,Ross Levine,Álvaro Quintanal-Villalonga,Triparna Sen,Andrew Chow,Charles M. Rudin +17 more
TL;DR: In this paper , the role of the lysine-specific demethylase 1 (LSD1) as a determinant of MHC-I expression, functional antigen presentation, and immune activation in SCLC in vitro and in vivo through evaluation of both human and immunocompetent mouse models.
References
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