Ina Hagedorn

TL;DR: It is demonstrated that T cells critically contribute to cerebral ischemia, but their detrimental effect neither depends on antigen recognition nor TCR costimulation or thrombus formation.

TL;DR: A novel and unexpected role of Tregs in a primary nonimmunologic disease state is defined, which reduced microvascular thrombus formation and improved cerebral reperfusion on stroke, as revealed by ultra-high-field magnetic resonance imaging at 17.6 Tesla.

TL;DR: The complementary DNA of the previously described factor XIIa inhibitor Infestin-4, cloned from the midgut of Triatoma infestans, was fused to recombinant human albumin (rHA) and analyzed in vitro as mentioned in this paper.

TL;DR: It is reported that platelets from Pld1−/− mice displayed impaired αIIbβ3 integrin activation in response to major agonists and defective glycoprotein Ib–dependent aggregate formation under high shear conditions, indicating that PLD1 may be a critical regulator of platelet activity in the setting of ischemic cardiovascular and cerebrovascular events.

TL;DR: Monocytes/macrophages are of central importance for healing after MI and appear to be an unrecognized new pathophysiological mechanism for left ventricular thrombus development after MI.