Tobias Schwarz

TL;DR: The identification of NOx4 as a major source of oxidative stress in stroke and demonstration of dramatic protection after stroke in mice by NOX4 deletion or NOX inhibition, opens up new avenues for treatment.

TL;DR: It is demonstrated that T cells critically contribute to cerebral ischemia, but their detrimental effect neither depends on antigen recognition nor TCR costimulation or thrombus formation.

TL;DR: A novel and unexpected role of Tregs in a primary nonimmunologic disease state is defined, which reduced microvascular thrombus formation and improved cerebral reperfusion on stroke, as revealed by ultra-high-field magnetic resonance imaging at 17.6 Tesla.

TL;DR: This study indicates that VWF is critically involved in cerebral ischemia, and targeted inhibition of the GPIbalpha-VWF pathway might become a promising therapeutic option.

TL;DR: This is the largest reported case series of CNO patients, showing that the range of associated clinical manifestations is rather heterogeneous, and confirms that the disease usually presents with an early teenage onset, but it may also occur in adults, even in the absence of mucocutaneous manifestations.