Journal ArticleDOI
Early detrimental T-cell effects in experimental cerebral ischemia are neither related to adaptive immunity nor thrombus formation
Christoph Kleinschnitz,Nicholas Schwab,Peter Kraft,Ina Hagedorn,Angela Dreykluft,Tobias Schwarz,Madeleine Austinat,Bernhard Nieswandt,Bernhard Nieswandt,Heinz Wiendl,Guido Stoll +10 more
TLDR
It is demonstrated that T cells critically contribute to cerebral ischemia, but their detrimental effect neither depends on antigen recognition nor TCR costimulation or thrombus formation.About:
This article is published in Blood.The article was published on 2010-05-06. It has received 322 citations till now. The article focuses on the topics: T cell & CD8.read more
Citations
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Journal ArticleDOI
The immunology of stroke: from mechanisms to translation
TL;DR: Gaining a better understanding of the reciprocal interaction between the immune system and the ischemic brain is essential to harness the full therapeutic potential of the immunology of stroke.
Journal ArticleDOI
Commensal microbiota affects ischemic stroke outcome by regulating intestinal γδ T cells.
Corinne Benakis,David Brea,Silvia Caballero,Giuseppe Faraco,Jamie Moore,Michelle Murphy,Giulia Sita,Gianfranco Racchumi,Lilan Ling,Eric G. Pamer,Eric G. Pamer,Costantino Iadecola,Josef Anrather +12 more
TL;DR: It is shown that antibiotic-induced alterations in the intestinal flora reduce ischemic brain injury in mice, an effect transmissible by fecal transplants, and that IL-10 and IL-17 are required for the neuroprotection afforded by intestinal dysbiosis.
Journal ArticleDOI
Inflammation and Stroke: An Overview
TL;DR: The inflammatory cascade from its starting point in the vasculature of the ischemic brain to the systemic immune response elicited by brain ischemia is outlined and potential immunomodulatory therapeutic approaches, including preconditioning and immune cell therapy are discussed.
Journal ArticleDOI
The immunology of acute stroke.
Ángel Chamorro,Andreas Meisel,Anna M. Planas,Xabier Urra,Diederik van de Beek,Roland Veltkamp +5 more
TL;DR: The multifaceted role of the immune system in the pathophysiology of acute stroke is discussed, with increased incidence of infections observed after acute stroke, and might result from activation of long-distance feedback loops between the CNS and peripheral immune organs.
Journal ArticleDOI
The role of peripheral immune cells in the CNS in steady state and disease
Marco Prinz,Josef Priller +1 more
TL;DR: Strategies for targeting peripheral immune cells to reduce CNS disease burden are assessed on the basis of observations of myeloid cells in the CNS parenchyma and at CNS–periphery interfaces.
References
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RAG-1-deficient mice have no mature B and T lymphocytes
Peter Mombaerts,John Iacomini,Randall S. Johnson,Karl Herrup,Susumu Tonegawa,Virginia E. Papaioannou +5 more
TL;DR: The introduction of a mutation in RAG-1 into the germline of mice via gene targeting in embryonic stem cells is described and it is shown that this mutation either activates or catalyzes the V(D)J recombination reaction of immunoglobulin and T cell receptor genes.
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Rat middle cerebral artery occlusion: evaluation of the model and development of a neurologic examination.
Joshua B. Bederson,Lawrence H. Pitts,Miles Tsuji,Merry C. Nishimura,Richard L. Davis,Henry M. Bartkowski +5 more
TL;DR: In this article, the authors examined the incidence and size of infarction after occlusion of different portions of the rat middle cerebral artery (MCA) in order to define the reliability and predictability of this model of brain ischemia.
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Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor.
TL;DR: It is suggested that PD-1 is involved in the maintenance of peripheral self-tolerance by serving as a negative regulator of immune responses in lymphocytes and monocytic cells following activation.
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Defective TCR expression in transgenic mice constructed using cDNA-based alpha- and beta-chain genes under the control of heterologous regulatory elements
TL;DR: Results show that successful generation of MHC class II‐restricted, OVA‐specific αβTCR transgenic mice was dependent upon combining cDNA‐ and genomic DNA‐based constructs for expression of the respective α‐ and β‐chains of the TCR.
Journal ArticleDOI
Differential T cell costimulatory requirements in CD28-deficient mice
Arda Shahinian,Klaus Pfeffer,Kelvin P. Lee,Thomas M. Kündig,Kenji Kishihara,Andrew Wakeham,Kazuhiro Kawai,Pamela S. Ohashi,Craig B. Thompson,Tak W. Mak +9 more
TL;DR: CD28 is not required for all T cell responses in vivo, suggesting that alternative costimulatory pathways may exist.