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Irina Grishkovskaya
Researcher at Research Institute of Molecular Pathology
Publications - 14
Citations - 268
Irina Grishkovskaya is an academic researcher from Research Institute of Molecular Pathology. The author has contributed to research in topics: Gene expression & Regulation of gene expression. The author has an hindex of 5, co-authored 14 publications receiving 104 citations. Previous affiliations of Irina Grishkovskaya include New England Biolabs & University of Vienna.
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A rapid, highly sensitive and open-access SARS-CoV-2 detection assay for laboratory and home testing
Max J. Kellner,Max J. Kellner,Max J. Kellner,James J. Ross,Jakob Schnabl,Marcus P. S. Dekens,Robert Heinen,Robert Heinen,Irina Grishkovskaya,Benedikt Bauer,Johannes Stadlmann,Johannes Stadlmann,Johannes Stadlmann,Luis Menéndez-Arias,Robert Fritsche-Polanz,Marianna Traugott,Tamara Seitz,Alexander Zoufaly,Manuela Födinger,Christoph Wenisch,Johannes Zuber,Johannes Zuber,Vienna Covid Diagnostics Initiative,Vienna Covid Diagnostics Initiative,Andrea Pauli,Julius Brennecke +25 more
TL;DR: A rapid, robust, highly sensitive and versatile RT-LAMP based SARS-CoV-2 detection assay that has substantially increased sensitivity and scalability, established a pipette-free version for home testing, and developed a version with open source enzymes that could be produced in any molecular biology setting.
Posted ContentDOI
Scalable, rapid and highly sensitive isothermal detection of SARS-CoV-2 for laboratory and home testing
Max J. Kellner,Max J. Kellner,Max J. Kellner,James J. Ross,Jakob Schnabl,Marcus P. S. Dekens,Robert Heinen,Robert Heinen,Irina Grishkovskaya,Benedikt Bauer,Johannes Stadlmann,Luis Menéndez-Arias,Robert Fritsche-Polanz,Marianna Traugott,Tamara Seitz,Alexander Zoufaly,Manuela Foedinger,Christoph Wenisch,Johannes Zuber,Johannes Zuber,Vienna Covid Diagnostics Initiative,Andrea Pauli,Julius Brennecke +22 more
TL;DR: A robust, highly sensitive and versatile RT-LAMP-based SARS-CoV-2 detection assay that is insensitive to carry-over contaminations is established and HomeDip-Lamp is developed for pipette-free Sars- CoV- 2 detection for low-resource environments.
Journal ArticleDOI
AKIRIN2 controls the nuclear import of proteasomes in vertebrates.
Melanie de Almeida,Melanie de Almeida,Matthias Hinterndorfer,Matthias Hinterndorfer,Hanna Brunner,Hanna Brunner,Irina Grishkovskaya,Kashish Singh,Kashish Singh,Alexander Schleiffer,Julian Jude,Sumit Deswal,Sumit Deswal,Robert Kalis,Robert Kalis,Milica Vunjak,Milica Vunjak,Thomas Lendl,Richard Imre,Elisabeth Roitinger,Tobias Neumann,Susanne Kandolf,Michael Schutzbier,Karl Mechtler,Gijs A. Versteeg,David Haselbach,Johannes Zuber,Johannes Zuber +27 more
TL;DR: In this paper, a CRISPR screening assay based on time-controlled Cas9 mutagenesis, intracellular immunostaining and fluorescence-activated cell sorting was developed to identify regulatory factors independent of their effects on cellular fitness.
Journal ArticleDOI
The linear ubiquitin chain assembly complex (LUBAC) generates heterotypic ubiquitin chains.
Alan Rodriguez Carvajal,Irina Grishkovskaya,Carlos Gomez Diaz,Antonia Vogel,Adar Sonn-Segev,Manish S. Kushwah,Katrin Schodl,Luiza Deszcz,Luiza Deszcz,Zsuzsanna Orban-Nemeth,Shinji Sakamoto,Karl Mechtler,Philipp Kukura,Tim Clausen,David Haselbach,Fumiyo Ikeda,Fumiyo Ikeda +16 more
TL;DR: In this paper, a 3D reconstruction of human linear ubiquitin chain assembly complex (LUBAC) was obtained by electron microscopy and reported its generation of heterotypic chains containing linear linkages with oxyester-linked branches.
Journal ArticleDOI
HUWE1 employs a giant substrate-binding ring to feed and regulate its HECT E3 domain.
Daniel B. Grabarczyk,Olga A Petrova,Luiza Deszcz,Robert Kurzbauer,Paul Murphy,Juraj Ahel,Antonia Vogel,Rebeca Gogova,Victoria Faas,Darja Kordic,Alexander Schleiffer,Anton Meinhart,Richard Imre,Anita Lehner,Jana Neuhold,Gerd Bader,Peggy Stolt-Bergner,Jark Böttcher,Bernhard Wolkerstorfer,Gerhard Fischer,Irina Grishkovskaya,David Haselbach,Dirk Kessler,Tim Clausen +23 more
TL;DR: Nematocida HUWE1 as mentioned in this paper adopts a remarkable snake-like structure, where the C-terminal HECT domain heads an extended alpha-solenoid body that coils in on itself and houses various protein-protein interaction modules.