J
Jack P. Antel
Researcher at Montreal Neurological Institute and Hospital
Publications - 540
Citations - 49656
Jack P. Antel is an academic researcher from Montreal Neurological Institute and Hospital. The author has contributed to research in topics: Multiple sclerosis & Microglia. The author has an hindex of 105, co-authored 519 publications receiving 43950 citations. Previous affiliations of Jack P. Antel include Université de Montréal & Howard Hughes Medical Institute.
Papers
More filters
Journal ArticleDOI
B-cell depletion with rituximab in relapsing-remitting multiple sclerosis.
Stephen L. Hauser,Emmanuelle Waubant,Douglas L. Arnold,Timothy Vollmer,Jack P. Antel,Robert J. Fox,Amit Bar-Or,Michael Panzara,Neena Sarkar,Sunil Agarwal,Annette Langer-Gould,Craig H. Smith +11 more
TL;DR: A single course of rituximab reduced inflammatory brain lesions and clinical relapses for 48 weeks and provides evidence of B-cell involvement in the pathophysiology of relapsing-remitting multiple sclerosis.
Journal ArticleDOI
Identification of a unique TGF-β–dependent molecular and functional signature in microglia
Oleg Butovsky,Mark P. Jedrychowski,Craig S. Moore,Ron Cialic,Amanda J. Lanser,Galina Gabriely,Thomas Koeglsperger,Ben Dake,Pauline M. Wu,Camille Doykan,Zain Fanek,LiPing Liu,Zhuoxun Chen,Jeffrey D. Rothstein,Richard M. Ransohoff,Steven P. Gygi,Jack P. Antel,Howard L. Weiner +17 more
TL;DR: It is found that TGF-β was required for the in vitro development of microglia that express the microglial molecular signature characteristic of adultmicroglia and that microglian were absent in the CNS of TGF -β1–deficient mice.
Journal ArticleDOI
Development of a multiple sclerosis functional composite as a clinical trial outcome measure
Gary Cutter,Monika Baier,Richard A. Rudick,Diane Cookfair,J. S. Fischer,John Petkau,Karl Syndulko,Brian G. Weinshenker,Jack P. Antel,Christian Confavreux,George W. Ellison,Fred D. Lublin,Aaron E. Miller,Stephen M. Rao,Stephen C. Reingold,Alan J. Thompson,Ernest Willoughby +16 more
TL;DR: A composite measure encompassing the major clinical dimensions of arm, leg and cognitive function was identified and termed the multiple sclerosis functional composite (MSFC), suggesting that the MSFC is more sensitive to change than the EDSS.
Journal ArticleDOI
Oral Fingolimod (FTY720) for Relapsing Multiple Sclerosis
Ludwig Kappos,Jack P. Antel,Giancarlo Comi,Xavier Montalban,Paul O'Connor,Chris H. Polman,Tomas Haas,Alexander Korn,Goeril Karlsson,Ernst Wilhelm Radue +9 more
TL;DR: In this proof-of-concept study, fingolimod reduced the number of lesions detected on MRI and clinical disease activity in patients with multiple sclerosis and both measures decreased in patients who switched from placebo to fingolIMod.
Journal ArticleDOI
Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor
Veit Rothhammer,Ivan D. Mascanfroni,Lukas Bunse,Maisa C. Takenaka,Jessica E. Kenison,Lior Mayo,Chun-Cheih Chao,Bonny Patel,Raymond Yan,Manon Blain,Jorge I. Alvarez,Hania Kebir,Niroshana Anandasabapathy,Guillermo Izquierdo,Steffen Jung,Nikolaus D. Obholzer,Nikolaus D. Obholzer,Nathalie Pochet,Nathalie Pochet,Clary B. Clish,Marco Prinz,Alexandre Prat,Jack P. Antel,Francisco J. Quintana +23 more
TL;DR: Findings suggest that IFN-Is produced in the CNS function in combination with metabolites derived from dietary tryptophan by the gut flora to activate AHR signaling in astrocytes and suppress CNS inflammation.