J
Jacob Raber
Researcher at Oregon Health & Science University
Publications - 253
Citations - 13602
Jacob Raber is an academic researcher from Oregon Health & Science University. The author has contributed to research in topics: Apolipoprotein E & Water maze. The author has an hindex of 53, co-authored 230 publications receiving 11862 citations. Previous affiliations of Jacob Raber include Scripps Health & University of California, San Francisco.
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Sex-differences in age-related cognitive decline in C57BL/6J mice associated with increased brain microtubule-associated protein 2 and synaptophysin immunoreactivity
TL;DR: Elevated levels of microtubule-associated protein 2 and synaptophysin may constitute a compensatory response to age-related functional decline in mice.
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Irradiation attenuates neurogenesis and exacerbates ischemia‐induced deficits
Jacob Raber,Yang Fan,Yang Fan,Yasuhiko Matsumori,Yasuhiko Matsumori,Zhengyan Liu,Zhengyan Liu,Philip Weinstein,Philip Weinstein,John R. Fike,Jialing Liu,Jialing Liu +11 more
TL;DR: Impairments after cerebral global ischemia under conditions of reduced neurogenesis support a role for the production of new cells in mediating functional recovery, and suggest that functional recovery after stroke may be attributed in part to neural regeneration.
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Apolipoprotein E and cognitive performance
Jacob Raber,Derek Wong,Gui Qiu Yu,Manuel Buttini,Robert W. Mahley,Robert E. Pitas,Lennart Mucke +6 more
TL;DR: Testing the spatial memory of transgenic mice carrying human forms of apolipoprotein E finds that it is impaired in mice with ApoE4 but not those with apoE3, even though the levels of β-amyloid in their brains are comparable.
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A WAVE-1 and WRP Signaling Complex Regulates Spine Density, Synaptic Plasticity, and Memory
Scott H. Soderling,Eric S. Guire,Stefanie Kaech,Jon White,Fang Zhang,Kevin Schutz,Lorene K. Langeberg,Gary Banker,Jacob Raber,John D. Scott +9 more
TL;DR: Gene targeting experiments in mice demonstrate that WRP anchoring to WAVE-1 is a homeostatic mechanism that contributes to neuronal development and the fidelity of synaptic connectivity, which implies that signaling through WAve-1 complexes is essential for neural plasticity and cognitive behavior.
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Loss of WAVE-1 causes sensorimotor retardation and reduced learning and memory in mice
Scott H. Soderling,Lorene K. Langeberg,Jacquelyn A. Soderling,Stephen M. Davee,Richard B. Simerly,Jacob Raber,John D. Scott +6 more
TL;DR: Targeted disruption of the WAVE-1 gene generated mice with reduced anxiety, sensorimotor retardation, and deficits in hippocampal-dependent learning and memory, analogous to the symptoms of patients with 3p-syndrome mental retardation who are haploinsufficient for WRP/MEGAP.