J
James A. Knowles
Researcher at University of Southern California
Publications - 121
Citations - 26985
James A. Knowles is an academic researcher from University of Southern California. The author has contributed to research in topics: Genome-wide association study & Gene. The author has an hindex of 49, co-authored 111 publications receiving 22785 citations. Previous affiliations of James A. Knowles include Zilkha Neurogenetic Institute.
Papers
More filters
Journal ArticleDOI
Genetic variants specific to aging-related verbal memory: Insights from GWASs in a population-based cohort.
Thalida Em Arpawong,Neil Pendleton,Krisztina Mekli,John J. McArdle,Margaret Gatz,Chris Armoskus,James A. Knowles,Carol A. Prescott +7 more
TL;DR: This first U.S. population-based GWAS study conducted on both age-related immediate and delayed verbal memory found that TOMM40 had effects independent of APOE e4 on both phenotypes, andConditional analyses indicate GWAS signals on rDR level were driven by APOE, whereas signals on IR change weredriven by TOMM 40.
Journal ArticleDOI
Increased CNV-region deletions in mild cognitive impairment (MCI) and Alzheimer's disease (AD) subjects in the ADNI sample.
Guia Guffanti,Federica Torri,Jerod M. Rasmussen,Andrew P. Clark,Anita Lakatos,Jessica A. Turner,James H. Fallon,Andrew J. Saykin,Michael W. Weiner,Marquis P. Vawter,James A. Knowles,Steven G. Potkin,Fabio Macciardi +12 more
TL;DR: The functional pathway analysis of the genes putatively affected by deletions of CNV-Regions reveals enrichment of genes implicated in axonal guidance, cell-cell adhesion, neuronal morphogenesis and differentiation, and an association between large deletions and the development of cognitive impairment.
Journal ArticleDOI
Evidence for Linkage and Association of GABRB3 and GABRA5 to Panic Disorder
Laura M. Hodges,Abby J. Fyer,Myrna M. Weissman,Mark W. Logue,Fatemeh Haghighi,Oleg V. Evgrafov,Allessandro Rotondo,James A. Knowles,Steven P. Hamilton +8 more
TL;DR: Findings provide genetic evidence for the involvement of the genes GABRB3 and GABRA5 in the susceptibility to PD, with a prominent parent-of-origin effect.
Journal ArticleDOI
Clinically effective OCD treatment prevents 5-HT1B receptor-induced repetitive behavior and striatal activation.
Emily V. Ho,Summer L. Thompson,William Katzka,Mitra F. Sharifi,James A. Knowles,Stephanie C. Dulawa +5 more
TL;DR: Novel 5-HT1BR-induced behaviors and striatal activation that were alleviated only by clinically effective pharmacological OCD treatment are reported.
Journal ArticleDOI
Parental Bonding and Hoarding in Obsessive-Compulsive Disorder
David Chen,O. Joseph Bienvenu,Janice Krasnow,Ying Wang,Marco A. Grados,Bernadette Cullen,Fernando S. Goes,Brion S. Maher,Benjamin D. Greenberg,Nicole C.R. McLaughlin,Steven A. Rasmussen,Abby J. Fyer,James A. Knowles,James T. McCracken,John Piacentini,Daniel A. Geller,David L. Pauls,S. Evelyn Stewart,Dennis L. Murphy,Yin Yao Shugart,Mark A. Riddle,Gerald Nestadt,Jack Samuels +22 more
TL;DR: Perceived poor maternal care, maternal overprotection, and maternal overcontrol are associated with hoarding in women with OCD, providing further support for a hoarding subtype of OCD and for sex-specific differences in etiologic pathways for hoarding.