Y
Yin Yao Shugart
Researcher at National Institutes of Health
Publications - 170
Citations - 13095
Yin Yao Shugart is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Single-nucleotide polymorphism & Population. The author has an hindex of 55, co-authored 170 publications receiving 12105 citations. Previous affiliations of Yin Yao Shugart include Johns Hopkins University & Fudan University.
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Journal ArticleDOI
Genome-wide association study identifies new susceptibility loci for Crohn disease and implicates autophagy in disease pathogenesis
John D. Rioux,John D. Rioux,Ramnik J. Xavier,Kent D. Taylor,Mark S. Silverberg,Philippe Goyette,Alan Huett,Todd Green,Petric Kuballa,M. Michael Barmada,Lisa W. Datta,Yin Yao Shugart,Anne M. Griffiths,Stephan R. Targan,Andrew Ippoliti,Edmond Jean Bernard,Ling Mei,Dan L. Nicolae,Miguel Regueiro,L. Philip Schumm,A. Hillary Steinhart,Jerome I. Rotter,Richard H. Duerr,Judy H. Cho,Mark J. Daly,Mark J. Daly,Steven R. Brant +26 more
TL;DR: It is demonstrated that ATG16L1 is expressed in intestinal epithelial cell lines and that functional knockdown of this gene abrogates autophagy of Salmonella typhimurium, and these findings suggest thatAutophagy and host cell responses to intracellular microbes are involved in the pathogenesis of Crohn disease.
Journal ArticleDOI
Autosomal recessive lissencephaly with cerebellar hypoplasia is associated with human RELN mutations
Susan E. Hong,Yin Yao Shugart,David T. Huang,Saad Al Shahwan,P. Ellen Grant,Jonathan O'b Hourihane,Neil D T Martin,Christopher A. Walsh +7 more
TL;DR: Although reelin was previously thought to function exclusively in brain, some humans with RELN mutations show abnormal neuromuscular connectivity and congenital lymphoedema, suggesting previously unsuspected functions for reelin in and outside of the brain.
Journal ArticleDOI
Mapping human genetic diversity in Asia
Mahmood Ameen Abdulla,Ikhlak Ahmed,Anunchai Assawamakin,Anunchai Assawamakin,Jong Bhak,Samir K. Brahmachari,Gayvelline C. Calacal,Amit Kumar Chaurasia,Chien-Hsiun Chen,Jieming Chen,Yuan-Tsong Chen,Jiayou Chu,Eva Maria Cutiongco-de la Paz,Maria Corazon A. De Ungria,Frederick C. Delfin,Juli Edo,Suthat Fuchareon,Ho Ghang,Takashi Gojobori,Junsong Han,Sheng Feng Ho,Boon Peng Hoh,Wei Huang,Hidetoshi Inoko,Pankaj Jha,Timothy A. Jinam,Li Jin,Jongsun Jung,Daoroong Kangwanpong,Jatupol Kampuansai,Giulia C. Kennedy,Preeti Khurana,Hyung Lae Kim,Kwangjoong Kim,Sangsoo Kim,Woo Yeon Kim,Kuchan Kimm,Ryosuke Kimura,Tomohiro Koike,Supasak Kulawonganunchai,Vikrant Kumar,Poh San Lai,Jong-Young Lee,Sunghoon Lee,Edison T. Liu,Partha P. Majumder,Kiran Kumar Mandapati,Sangkot Marzuki,Wayne Mitchell,Wayne Mitchell,Mitali Mukerji,Kenji Naritomi,Chumpol Ngamphiw,Norio Niikawa,Nao Nishida,Bermseok Oh,Sangho Oh,Jun Ohashi,Akira Oka,Rick Twee-Hee Ong,Carmencita Padilla,Prasit Palittapongarnpim,Henry B. Perdigon,Maude E. Phipps,Maude E. Phipps,Eileen Png,Yoshiyuki Sakaki,Jazelyn M. Salvador,Yuliana Sandraling,Vinod Scaria,Mark Seielstad,Mohd Ros Sidek,Amit Sinha,Metawee Srikummool,Herawati Sudoyo,Sumio Sugano,Helena Suryadi,Yoshiyuki Suzuki,Kristina A. Tabbada,Adrian Tan,Katsushi Tokunaga,Sissades Tongsima,Lilian P. Villamor,Eric Wang,Ying Wang,Haifeng Wang,Jer-Yuarn Wu,Huasheng Xiao,Shuhua Xu,Jin Ok Yang,Yin Yao Shugart,Hyang Sook Yoo,Wentao Yuan,Guoping Zhao,Bin Alwi Zilfalil +94 more
TL;DR: The results suggest that there may have been a single major migration of people into Asia and a subsequent south-to-north migration across the continent, and that genetic ancestry is strongly correlated with linguistic affiliations as well as geography.
Journal ArticleDOI
Exome sequencing and the genetic basis of complex traits
Adam Kiezun,Kiran V. Garimella,Ron Do,Ron Do,Nathan O. Stitziel,Nathan O. Stitziel,Benjamin M. Neale,Benjamin M. Neale,Paul J. McLaren,Paul J. McLaren,Namrata Gupta,Pamela Sklar,Patrick F. Sullivan,Jennifer L. Moran,Christina M. Hultman,Paul Lichtenstein,Patrik K. E. Magnusson,Thomas Lehner,Yin Yao Shugart,Alkes L. Price,Alkes L. Price,Paul I.W. de Bakker,Paul I.W. de Bakker,Paul I.W. de Bakker,Shaun Purcell,Shamil R. Sunyaev,Shamil R. Sunyaev +26 more
TL;DR: Exome sequencing methods and their applications in studies to identify the genetic basis of human complex traits are presented and include analyses of the whole-exome sequences of 438 individuals from across several studies.
Journal ArticleDOI
Abnormal cerebellar development and axonal decussation due to mutations in AHI1 in Joubert syndrome.
Russell J. Ferland,Wafaa Eyaid,Randall V. Collura,Laura D Tully,R. Sean Hill,Doha M. Al-Nouri,Ahmed Al-Rumayyan,Meral Topçu,Generoso G. Gascon,Adria Bodell,Yin Yao Shugart,Maryellen Ruvolo,Christopher A. Walsh,Christopher A. Walsh +13 more
TL;DR: Comparative genetic analysis of AHI1 indicates that it has undergone positive evolutionary selection along the human lineage, and changes in A HI1 may have been important in the evolution of human-specific motor behaviors.