G
Guia Guffanti
Researcher at Harvard University
Publications - 65
Citations - 3594
Guia Guffanti is an academic researcher from Harvard University. The author has contributed to research in topics: Genome-wide association study & Gene. The author has an hindex of 25, co-authored 59 publications receiving 2826 citations. Previous affiliations of Guia Guffanti include University of York & University of California, Irvine.
Papers
More filters
Journal ArticleDOI
Hippocampal atrophy as a quantitative trait in a genome-wide association study identifying novel susceptibility genes for Alzheimer's disease.
Steven G. Potkin,Guia Guffanti,Guia Guffanti,Anita Lakatos,Jessica A. Turner,Frithjof Kruggel,James H. Fallon,Andrew J. Saykin,Alessandro Orro,Sara Lupoli,Erika Salvi,Michael P. Weiner,Fabio Macciardi,Fabio Macciardi +13 more
TL;DR: Using hippocampal atrophy as a quantitative phenotype in a genome-wide scan, candidate risk genes for sporadic Alzheimer's disease that merit further investigation are identified.
Journal ArticleDOI
Largest GWAS of PTSD (N=20 070) yields genetic overlap with schizophrenia and sex differences in heritability
Laramie E. Duncan,Andrew Ratanatharathorn,Allison E. Aiello,Lynn M. Almli,Amstadter Ab,Allison E. Ashley-Koch,Dewleen G. Baker,Jean C. Beckham,Laura J. Bierut,Jonathan Ian Bisson,Bekh Bradley,Chia-Yen Chen,Shareefa Dalvie,Lindsay A. Farrer,Sandro Galea,Melanie E. Garrett,Joel Gelernter,Guia Guffanti,Michael A. Hauser,Eric O. Johnson,Ronald C. Kessler,Nathan A. Kimbrel,Nathan A. Kimbrel,Anthony P. King,Nastassja Koen,Nastassja Koen,Henry R. Kranzler,Mark W. Logue,Adam X. Maihofer,Alicia R. Martin,Mark W. Miller,Mark W. Miller,Rajendra A. Morey,Nicole R. Nugent,John P. Rice,Stephan Ripke,Stephan Ripke,Stephan Ripke,Andrea L. Roberts,Nancy L. Saccone,Jordan W. Smoller,Jordan W. Smoller,Dan J. Stein,Dan J. Stein,Murray B. Stein,Murray B. Stein,Jennifer A. Sumner,Monica Uddin,Robert J. Ursano,Derek E. Wildman,Rachel Yehuda,Hongyu Zhao,Mark J. Daly,Mark J. Daly,Israel Liberzon,Kerry J. Ressler,Kerry J. Ressler,Caroline M. Nievergelt,Caroline M. Nievergelt,Karestan C. Koenen,Karestan C. Koenen +60 more
TL;DR: The results demonstrate genetic influences on the development of PTSD, identify shared genetic risk between PTSD and other psychiatric disorders and highlight the importance of multiethnic/racial samples.
Journal ArticleDOI
International meta-analysis of PTSD genome-wide association studies identifies sex- and ancestry-specific genetic risk loci
Caroline M. Nievergelt,Caroline M. Nievergelt,Adam X. Maihofer,Adam X. Maihofer,Torsten Klengel,Torsten Klengel,Elizabeth G. Atkinson,Elizabeth G. Atkinson,Chia-Yen Chen,Chia-Yen Chen,Karmel W. Choi,Karmel W. Choi,Jonathan R. I. Coleman,Shareefa Dalvie,Laramie E. Duncan,Joel Gelernter,Joel Gelernter,Daniel F. Levey,Daniel F. Levey,Mark W. Logue,Renato Polimanti,Renato Polimanti,Allison C. Provost,Andrew Ratanatharathorn,Murray B. Stein,Murray B. Stein,Katy Torres,Katy Torres,Allison E. Aiello,Lynn M. Almli,Ananda B. Amstadter,Søren Bo Andersen,Ole A. Andreassen,Paul A. Arbisi,Allison E. Ashley-Koch,S. Bryn Austin,Esmina Avdibegović,Dragan Babić,Marie Bækvad-Hansen,Marie Bækvad-Hansen,Dewleen G. Baker,Dewleen G. Baker,Jean C. Beckham,Laura J. Bierut,Jonathan Ian Bisson,Marco P. Boks,Elizabeth A. Bolger,Anders D. Børglum,Anders D. Børglum,Bekh Bradley,Megan Brashear,Gerome Breen,Richard A. Bryant,A.C. Bustamante,Jonas Bybjerg-Grauholm,Jonas Bybjerg-Grauholm,Joseph R. Calabrese,José Miguel Caldas de Almeida,Anders M. Dale,Mark J. Daly,Nikolaos P. Daskalakis,Jürgen Deckert,Douglas L. Delahanty,Michelle F. Dennis,Seth G. Disner,Katharina Domschke,Alma Dzubur-Kulenovic,Christopher R. Erbes,Alexandra Evans,Lindsay A. Farrer,Norah C. Feeny,Janine D. Flory,David Forbes,Carol E. Franz,Sandro Galea,Melanie E. Garrett,Bizu Gelaye,Elbert Geuze,Charles F. Gillespie,Aferdita Goci Uka,Scott D. Gordon,Guia Guffanti,Rasha Hammamieh,Supriya Harnal,Michael A. Hauser,Andrew C. Heath,Sian M. J. Hemmings,David M. Hougaard,David M. Hougaard,Miro Jakovljević,Marti Jett,Eric O. Johnson,Ian Jones,Tanja Jovanovic,Xue Jun Qin,Angela G. Junglen,Karen-Inge Karstoft,Milissa L. Kaufman,Ronald C. Kessler,Alaptagin Khan,Nathan A. Kimbrel,Anthony P. King,Nastassja Koen,Henry R. Kranzler,Henry R. Kranzler,William S. Kremen,William S. Kremen,Bruce R. Lawford,Lauren A.M. Lebois,Catrin Lewis,Sarah D. Linnstaedt,Adriana Lori,Bozo Lugonja,Jurjen J. Luykx,Michael J. Lyons,Jessica L. Maples-Keller,Charles R. Marmar,Alicia R. Martin,Alicia R. Martin,Nicholas G. Martin,Douglas Maurer,Matig R. Mavissakalian,Alexander C. McFarlane,Regina E. McGlinchey,Katie A. McLaughlin,Samuel A. McLean,Sarah McLeay,Divya Mehta,William P. Milberg,Mark W. Miller,Rajendra A. Morey,Charles P. Morris,Ole Mors,Ole Mors,Preben Bo Mortensen,Preben Bo Mortensen,Benjamin M. Neale,Benjamin M. Neale,Elliot C. Nelson,Merete Nordentoft,Merete Nordentoft,Sonya B. Norman,Sonya B. Norman,Meaghan O'Donnell,Holly K. Orcutt,Matthew S. Panizzon,Edward S. Peters,Alan L. Peterson,Matthew Peverill,Robert H. Pietrzak,Robert H. Pietrzak,Melissa A. Polusny,John P. Rice,Stephan Ripke,Stephan Ripke,Stephan Ripke,Victoria B. Risbrough,Victoria B. Risbrough,Andrea L. Roberts,Alex O. Rothbaum,Barbara O. Rothbaum,Peter Roy-Byrne,Kenneth J. Ruggiero,Ariane Rung,Bart P. F. Rutten,Nancy L. Saccone,Sixto E. Sanchez,Dick Schijven,Soraya Seedat,Antonia V. Seligowski,Julia S. Seng,Christina M. Sheerin,Derrick Silove,Alicia K. Smith,Jordan W. Smoller,Jordan W. Smoller,Scott R. Sponheim,Dan J. Stein,Jennifer S. Stevens,Jennifer A. Sumner,Martin H. Teicher,Wesley K. Thompson,Edward J. Trapido,Monica Uddin,Robert J. Ursano,Leigh van den Heuvel,Miranda Van Hooff,Eric Vermetten,Christiaan H. Vinkers,Joanne Voisey,Yunpeng Wang,Yunpeng Wang,Zhewu Wang,Zhewu Wang,Thomas Werge,Thomas Werge,Michelle A. Williams,Douglas E. Williamson,Sherry Winternitz,Christiane Wolf,Erika J. Wolf,Jonathan D. Wolff,Rachel Yehuda,Rachel Yehuda,Ross McD. Young,Keith A. Young,Hongyu Zhao,Lori A. Zoellner,Israel Liberzon,Kerry J. Ressler,Kerry J. Ressler,Magali Haas,Karestan C. Koenen,Karestan C. Koenen +213 more
TL;DR: A GWAS from the Psychiatric Genomics Consortium is reported in which two risk loci in European ancestry and one locus in African ancestry individuals are identified and it is found that PTSD is genetically correlated with several other psychiatric traits.
Journal ArticleDOI
A Genome-Wide Association Study of Schizophrenia Using Brain Activation as a Quantitative Phenotype
Steven G. Potkin,Jessica A. Turner,Guia Guffanti,Guia Guffanti,Anita Lakatos,James H. Fallon,Dana D Nguyen,Daniel H. Mathalon,Daniel H. Mathalon,Judith M. Ford,Judith M. Ford,John Lauriello,John Lauriello,Fabio Macciardi +13 more
TL;DR: Combining imaging and genetic data from a GWAS identified genes related to forebrain development and stress response, already implicated in schizophrenic dysfunction, as affecting prefrontal efficiency.
Journal ArticleDOI
A genome-wide association study of post-traumatic stress disorder identifies the retinoid-related orphan receptor alpha (RORA) gene as a significant risk locus
Mark W. Logue,Clinton T. Baldwin,Guia Guffanti,Efi Melista,Erika J. Wolf,Erika J. Wolf,Annemarie F. Reardon,Monica Uddin,Derek E. Wildman,Sandro Galea,Karestan C. Koenen,Mark W. Miller,Mark W. Miller +12 more
TL;DR: The results of the first genome-wide association study of post-traumatic stress disorder performed using trauma-exposed white non-Hispanic participants from a cohort of veterans and their intimate partners and several single-nucleotide polymorphisms (SNPs) yielded evidence of association.