James A. Knowles

TL;DR: In the largest assessment of substance use among individuals with severe psychotic illness to date, the odds of smoking and alcohol and other substance use are found to be dramatically higher than recent estimates of Substance use in mild mental illness.

TL;DR: The results indicate that there is some genetic overlap between these two phenotypically-related neuropsychiatric disorders, but suggest that the two disorders have distinct genetic architectures.

TL;DR: Patients with severe human immunodeficiency virus-associated PAH should be considered for long-term epoprostenol infusion in association with CART, according to multivariate analysis and prognostic factors.

TL;DR: This is the first digital human brain atlas to incorporate neuroimaging, high‐resolution histology, and chemoarchitecture across a complete adult female brain, consisting of magnetic resonance imaging (MRI), diffusion‐weighted imaging (DWI), and 1,356 large‐format cellular resolution (1 µm/pixel) Nissl and immunohistochemistry anatomical plates.

TL;DR: Although no SNPs were identified to be associated with OCD at a genome-wide significant level in the combined trio–case–control sample, a significant enrichment of methylation QTLs and frontal lobe expression quantitative trait loci (eQTLs) was observed within the top-ranked SNPs, suggesting these top signals may have a broad role in gene expression in the brain, and possibly in the etiology of OCD.