James A. Knowles

TL;DR: This study lays the groundwork for the eventual identification of common TS susceptibility variants in larger cohorts and helps to provide a more complete understanding of the full genetic architecture of this disorder.

TL;DR: A large sample size allowed us to test the heritability and genetic correlation of BD subtypes and investigate their genetic overlap with schizophrenia and major depressive disorder, and results point to a partial difference in the genetic architecture ofBD subtypes as currently defined.

TL;DR: In this paper, a five-factor structural model of OCD symptoms, including separate factor analyses employing individual symptoms and symptom categories, as well as sibling concordance, was presented.

TL;DR: DNA extracted from venous blood in a Caucasian subset of the interviewed OCD patients was genotyped to investigate polymorphisms in genes involved in monoamine function and previously hypothesized to be relevant to OCD, consistent with the hypothesis that hoarding represents a unique symptom subtype in OCD with a distinctive clinical and psychobiological profile.

TL;DR: The GWAS signals were enriched for SNPs strongly associated with variations in brain gene expression levels (expression quantitative loci, or eQTLs), suggesting the presence of true functional variants that contribute to risk of these disorders.