J
James A. Knowles
Researcher at University of Southern California
Publications - 121
Citations - 26985
James A. Knowles is an academic researcher from University of Southern California. The author has contributed to research in topics: Genome-wide association study & Gene. The author has an hindex of 49, co-authored 111 publications receiving 22785 citations. Previous affiliations of James A. Knowles include Zilkha Neurogenetic Institute.
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Journal ArticleDOI
Effect of RNA integrity on uniquely mapped reads in RNA-Seq.
Emily Chen,Tade Souaiaia,Jennifer Herstein,Oleg V. Evgrafov,Valeria N. Spitsyna,Danea F Rebolini,James A. Knowles +6 more
TL;DR: It is discovered that gene expression read results are influenced by RNA quality when a common library construction protocol is used, facilitating the investigation of disease tissues.
A mega-analysis of genome-wide association studies for major depressive disorder
Stephan Ripke,Naomi R. Wray,Cathryn M. Lewis,S. P. Hamilton,Myrna M. Weissman,Gerome Breen,Enda M. Byrne,D. H. R. Blackwood,Dorret I. Boomsma,Sven Cichon,Andrew C. Heath,Florian Holsboer,Susanne Lucae,P. A. F. Madden,Nicholas G. Martin,Peter McGuffin,Pierandrea Muglia,Markus M. Noethen,B. P. Penninx,M. L. Pergadia,James B. Potash,Marcella Rietschel,Danyu Lin,Bertram Müller-Myhsok,Jianxin Shi,Stacy Steinberg,Hans-Jörgen Grabe,Paul Lichtenstein,Patrik K. E. Magnusson,Roy H. Perlis,Martin Preisig,Jordan W. Smoller,Kari Stefansson,Rudolf Uher,Zoltán Kutalik,Katherine E. Tansey,A. Teumer,Alexander Viktorin,Michael R. Barnes,Thomas Bettecken,Elisabeth B. Binder,René Breuer,Victor M. Castro,Susanne Churchill,William Coryell,Nicholas John Craddock,Ian W. Craig,Darina Czamara,E.J.C. de Geus,Franziska Degenhardt,A. E. Farmer,Maurizio Fava,John Frank,Vivian S. Gainer,Patience J. Gallagher,Scott D. Gordon,Sergey Goryachev,Marcela González Gross,Michel Guipponi,Anjali K. Henders,Stefan Herms,Ian B. Hickie,Susanne Hoefels,Witte J.G. Hoogendijk,Jouke-Jan Hottenga,Dan V. Iosifescu,Marcus Ising,Ian Jones,Lisa Jones,T. Jung-Ying,James A. Knowles,Isaac S. Kohane,Martin A. Kohli,Ania Korszun,Mikael Landén,William Lawson,Glyn Lewis,Donald J. MacIntyre,W. Maier,Manuel Mattheisen,Patrick J. McGrath,Andrew M. McIntosh,Alan W. McLean,Christel M. Middeldorp,Lefkos T. Middleton,G. M. Montgomery,Shawn N. Murphy,Matthias Nauck,Willem A. Nolen,Dale R. Nyholt,Michael Conlon O'Donovan,Hogni Oskarsson,N L Pedersen,William A. Scheftner,Andrea Schulz,Thomas G. Schulze,Stanley I. Shyn,Engilbert Sigurdsson,Susan L. Slager,Johannes H. Smit,Hreinn Stefansson,Michael Steffens,Thorgeir E. Thorgeirsson,F. Tozzi,Jens Treutlein,Manfred Uhr,E. J. C. G. van den Oord,G van Grootheest,Henry Völzke,Jeffrey B. Weilburg,Gonneke Willemsen,Frans G. Zitman,Benjamin M. Neale,Mark J. Daly,Douglas F. Levinson,Patrick F. Sullivan +115 more
TL;DR: The authors conducted a genome-wide association studies (GWASA) mega-analysis for major depressive disorder (MDD) and found that only 15 SNPs exceeded genomewide significance (P<5 x 10(-8)), and all were in a 248 kb interval of high LD on 3p21.1 (chr3:52 425 083-53 822 102, minimum P=5.9 x 10−9) at rs2535629).
Journal ArticleDOI
Serotonin Transporter Polymorphisms in Patients With Portopulmonary Hypertension
Kari E. Roberts,Michael B. Fallon,Michael J. Krowka,Raymond L. Benza,James A. Knowles,David B. Badesch,Robert S. Brown,Darren B. Taichman,James F. Trotter,Steven Zacks,Evelyn M. Horn,Steven M. Kawut +11 more
TL;DR: SERT polymorphisms are not associated with the risk of PPHTN in patients with advanced liver disease, and other clinical or genetic risk factors may play a role in this complication of portal hypertension.
Journal ArticleDOI
An investigation of doubt in obsessive–compulsive disorder
Jack Samuels,O. Joseph Bienvenu,Janice Krasnow,Ying Wang,Marco A. Grados,Bernadette Cullen,Fernando S. Goes,Brion S. Maher,Benjamin D. Greenberg,Nicole C.R. McLaughlin,Steven A. Rasmussen,Abby J. Fyer,James A. Knowles,Paul S. Nestadt,James T. McCracken,John Piacentini,Daniel A. Geller,David L. Pauls,S. Evelyn Stewart,Dennis L. Murphy,Yin Yao Shugart,Vidya Kamath,Arnold Bakker,Mark A. Riddle,Gerald Nestadt +24 more
TL;DR: Doubt is associated with important clinical features of OCD, including impairment and cognitive-behavioral treatment response, and is strongly associated with global impairment and poor response to cognitive behavioral treatment (CBT), even adjusting for OCD severity.
Journal ArticleDOI
Association and linkage analysis of candidate genes GRP, GRPR, CRHR1, and TACR1 in panic disorder†
Laura M. Hodges,Myrna M. Weissman,Fatemeh Haghighi,Ramiro Costa,Oscar Bravo,Oleg V. Evgrafov,James A. Knowles,Abby J. Fyer,Steven P. Hamilton +8 more
TL;DR: Limiting support for genetic linkage to TACR1 and GRP findings in large case‐control PD samples may provide more definitive evidence implicating these loci in the genetic etiology of PD.