Jamie E. Posey

TL;DR: Functional genetic analysis of mutations in one gene, ponA1, demonstrated an in vitro growth advantage in the presence of the drug rifampicin, and evidence of positive selection in an additional 39 genomic regions in resistant isolates was found.

TL;DR: In this article, the authors identified genome-wide signatures of positive selection specific to the 47 drug-resistant strains of M. tuberculosis and identified positive selection in 39 genomic regions in resistant isolates, encoding components in cell wall biosynthesis, transcriptional regulation and DNA repair pathways.

TL;DR: Genomic sequencing was used to understand the establishment and dispersion of MDR Mycobacterium tuberculosis within a group of immigrants to the United States and revealed a highly prevalent MDR strain that included several closely related but distinct allelic variants within Thailand, rather than a single outbreak.

TL;DR: Experts in tuberculosis and HIV care, researchers, healthcare providers, public health experts, and industry representatives, as well as representatives of pertinent US federal agencies assembled at a workshop proposed by the Diagnostics Working Group of the Federal Tuberculosis Taskforce to review the state of tuberculosis diagnostics development in adult and pediatric populations.