G
Gillian Mitchell
Researcher at Peter MacCallum Cancer Centre
Publications - 142
Citations - 12485
Gillian Mitchell is an academic researcher from Peter MacCallum Cancer Centre. The author has contributed to research in topics: Breast cancer & Cancer. The author has an hindex of 38, co-authored 138 publications receiving 10800 citations. Previous affiliations of Gillian Mitchell include University of British Columbia & University of Melbourne.
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Journal ArticleDOI
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and recurrent ovarian cancer: a proof-of-concept trial
Andrew Tutt,Mark E. Robson,Judy Garber,Susan M. Domchek,M. William Audeh,Jeffrey N. Weitzel,Michael Friedlander,Banu Arun,Niklas Loman,Rita K. Schmutzler,Andrew M Wardley,Gillian Mitchell,H. M. Earl,Mark Wickens,James Carmichael +14 more
TL;DR: Findings from this phase 2 study provide positive proof of concept of the efficacy and tolerability of genetically targeted treatment with olaparib in BRCA-mutated advanced ovarian cancer.
Journal ArticleDOI
Oral poly(ADP-ribose) polymerase inhibitor olaparib in patients with BRCA1 or BRCA2 mutations and advanced breast cancer
Andrew Tutt,Mark E. Robson,Judy Garber,Susan M. Domchek,M. W. Audeh,J. N. Weitzel,Michael Friedlander,B. K. Arun,Niklas Loman,Rita K. Schmutzler,Andrew M Wardley,Gillian Mitchell,H. M. Earl,Mark Wickens,J. Carmichael +14 more
TL;DR: The results of this study provide positive proof of concept for PARP inhibition in BRCA-deficient breast cancers and shows a favourable therapeutic index for a novel targeted treatment strategy in patients with tumours that have genetic loss of function of BRCa1-associated orBRCA2-associated DNA repair.
Journal ArticleDOI
Olaparib Monotherapy in Patients With Advanced Cancer and a Germline BRCA1/2 Mutation
Bella Kaufman,Ronnie Shapira-Frommer,Rita K. Schmutzler,M. William Audeh,Michael Friedlander,Judith Balmaña,Gillian Mitchell,Georgeta Fried,Salomon M. Stemmer,Ayala Hubert,Ora Rosengarten,Mariana Steiner,Niklas Loman,Karin Bowen,Anitra Fielding,Susan M. Domchek +15 more
TL;DR: Responses to olaparib were observed across different tumor types associated with germline BRCA1/2 mutations, and warrants further investigation in confirmatory studies.
Journal ArticleDOI
BRCA Mutation Frequency and Patterns of Treatment Response in BRCA Mutation–Positive Women With Ovarian Cancer: A Report From the Australian Ovarian Cancer Study Group
Kathryn Alsop,Sian Fereday,Cliff Meldrum,Anna deFazio,Catherine Emmanuel,Joshy George,Alexander Dobrovic,Michael J. Birrer,Penelope M. Webb,Colin J.R. Stewart,Michael Friedlander,Stephen B. Fox,David D.L. Bowtell,Gillian Mitchell +13 more
TL;DR: The data supports the recommendation that germ-line BRCA1/2 testing should be offered to all women diagnosed with nonmucinous, ovarian carcinoma, regardless of family history, and supports the advent of poly(ADP-ribose) polymerase inhibitor trials.
Journal ArticleDOI
Association of type and location of BRCA1 and BRCA2 mutations with risk of breast and ovarian cancer.
Timothy R. Rebbeck,Nandita Mitra,Fei Wan,Olga M. Sinilnikova,Sue Healey,Lesley McGuffog,Sylvie Mazoyer,Georgia Chenevix-Trench,Douglas F. Easton,Antonis C. Antoniou,Katherine L. Nathanson,Yael Laitman,Anya Kushnir,Shani Paluch-Shimon,Raanan Berger,Jamal Zidan,Eitan Friedman,Hans Ehrencrona,Hans Ehrencrona,Marie Stenmark-Askmalm,Zakaria Einbeigi,Niklas Loman,Katja Harbst,Johanna Rantala,Beatrice Melin,Dezheng Huo,Olufunmilayo I. Olopade,Joyce Seldon,Patricia A. Ganz,Robert L. Nussbaum,Salina B. Chan,Kunle Odunsi,Simon A. Gayther,Susan M. Domchek,Banu Arun,Karen H. Lu,Gillian Mitchell,Gillian Mitchell,Beth Y. Karlan,Christine Walsh,Jenny Lester,Andrew K. Godwin,Harsh B. Pathak,Eric A. Ross,Mary B. Daly,Alice S. Whittemore,Esther M. John,Alexander Miron,Mary Beth Terry,Wendy K. Chung,David E. Goldgar,Saundra S. Buys,Ramūnas Janavičius,Laima Tihomirova,Nadine Tung,Cecilia M. Dorfling,Elizabeth J. van Rensburg,Linda Steele,Susan L. Neuhausen,Yuan Chun Ding,Bent Ejlertsen,Anne-Marie Gerdes,Thomas Hansen,Teresa Ramón y Cajal,Ana Osorio,Javier Benitez,Javier Godino,Maria-Isabel Tejada,Mercedes Durán,Jeffrey N. Weitzel,Kristie Bobolis,Sharon Sand,Annette Fontaine,Antonella Savarese,Barbara Pasini,Bernard Peissel,Bernardo Bonanni,Daniela Zaffaroni,Francesca Vignolo-Lutati,Giulietta Scuvera,Giuseppe Giannini,Loris Bernard,Maurizio Genuardi,Paolo Radice,Riccardo Dolcetti,Siranoush Manoukian,Valeria Pensotti,Viviana Gismondi,Drakoulis Yannoukakos,Florentia Fostira,Judy Garber,Diana Torres,Muhammad Usman Rashid,Ute Hamann,Susan Peock,Debra Frost,Radka Platte,D. Gareth Evans,Rosalind A. Eeles,Rosemarie Davidson,Diana Eccles,Trevor Cole,Jackie Cook,Carole Brewer,Shirley Hodgson,Patrick J. Morrison,Lisa Walker,Mary Porteous,M. John Kennedy,Louise Izatt,Julian Adlard,Alan Donaldson,Steve Ellis,Priyanka Sharma,Rita K. Schmutzler,Barbara Wappenschmidt,Alexandra Becker,Kerstin Rhiem,Eric Hahnen,Christoph Engel,Alfons Meindl,Stefanie Engert,Nina Ditsch,Norbert Arnold,Hans Jörg Plendl,Christoph Mundhenke,Dieter Niederacher,Markus C. Fleisch,Christian Sutter,Claus R. Bartram,Nicola Dikow,Shan Wang-Gohrke,Dorothea Gadzicki,Doris Steinemann,Karin Kast,Marit Beer,Raymonda Varon-Mateeva,Andrea Gehrig,Bernhard H. F. Weber,Dominique Stoppa-Lyonnet,Dominique Stoppa-Lyonnet,Claude Houdayer,Claude Houdayer,Muriel Belotti,Marion Gauthier-Villars,Francesca Damiola,Nadia Boutry-Kryza,Christine Lasset,Hagay Sobol,Jean-Philippe Peyrat,Danièle Muller,Jean-Pierre Fricker,Marie-Agnès Collonge-Rame,Isabelle Mortemousque,Catherine Noguès,Etienne Rouleau,Claudine Isaacs,Anne De Paepe,Bruce Poppe,Kathleen Claes,Kim De Leeneer,Marion Piedmonte,Gustavo C. Rodriguez,Katie Wakely,John F. Boggess,Stephanie V. Blank,Jack Basil,Masoud Azodi,Kelly-Anne Phillips,Kelly-Anne Phillips,Trinidad Caldés,Miguel de la Hoya,Atocha Romero,Heli Nevanlinna,Kristiina Aittomäki,Annemarie H. van der Hout,Frans B. L. Hogervorst,Senno Verhoef,J. Margriet Collée,Caroline Seynaeve,Jan C. Oosterwijk,Johannes J. P. Gille,Juul T. Wijnen,Encarna B. Gomez Garcia,Carolien M. Kets,Margreet G. E. M. Ausems,Cora M. Aalfs,Peter Devilee,Arjen R. Mensenkamp,Ava Kwong,Edith Olah,János Papp,Orland Diez,Conxi Lázaro,Esther Darder,Ignacio Blanco,Mónica Salinas,Anna Jakubowska,Jan Lubinski,Jacek Gronwald,Katarzyna Jaworska-Bieniek,Katarzyna Durda,Grzegorz Sukiennicki,Tomasz Huzarski,Tomasz Byrski,Cezary Cybulski,Aleksandra Tołoczko-Grabarek,Elżbieta Złowocka-Perłowska,Janusz Menkiszak,Adalgeir Arason,Rosa B. Barkardottir,Jacques Simard,Rachel Laframboise,Marco Montagna,Simona Agata,Elisa Alducci,Ana Peixoto,Manuel R. Teixeira,Amanda B. Spurdle,Min Hyuk Lee,Sue K. Park,Sung-Won Kim,Tara M. Friebel,Fergus J. Couch,Noralane M. Lindor,Vernon S. Pankratz,Lucia Guidugli,Xianshu Wang,Marc Tischkowitz,Marc Tischkowitz,Lenka Foretova,Joseph Vijai,Kenneth Offit,Mark E. Robson,Rohini Rau-Murthy,Noah D. Kauff,Anneliese Fink-Retter,Christian F. Singer,Christine Rappaport,Daphne Gschwantler-Kaulich,Georg Pfeiler,Muy-Kheng Tea,Andreas Berger,Mark H. Greene,Phuong L. Mai,Evgeny N. Imyanitov,Amanda E. Toland,Leigha Senter,Anders Bojesen,Inge Søkilde Pedersen,Anne-Bine Skytte,Lone Sunde,Mads Thomassen,Sanne Traasdahl Moeller,Torben A Kruse,Uffe Birk Jensen,Maria A. Caligo,Paolo Aretini,Soo Hwang Teo,Christina G. Selkirk,Peter J. Hulick,Irene L. Andrulis +261 more
TL;DR: In this paper, the relationship between specific mutations in BRCA1 and cancer risk has been investigated and limited information about the relationship has been available about specific mutations for specific mutations.