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Aurélie Fricot
Researcher at French Institute of Health and Medical Research
Publications - 15
Citations - 787
Aurélie Fricot is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Ineffective erythropoiesis & Erythroblast. The author has an hindex of 9, co-authored 12 publications receiving 604 citations. Previous affiliations of Aurélie Fricot include Centre national de la recherche scientifique & Paris Descartes University.
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Journal ArticleDOI
An activin receptor IIA ligand trap corrects ineffective erythropoiesis in β-thalassemia
Michael Dussiot,Thiago Trovati Maciel,Aurélie Fricot,Céline Chartier,Olivier Negre,Joel Veiga,Damien Grapton,Etienne Paubelle,Emmanuel Payen,Yves Beuzard,Philippe Leboulch,Jean-Antoine Ribeil,Jean-Benoît Arlet,Francine Côté,Geneviève Courtois,Yelena Ginzburg,Thomas O. Daniel,Rajesh Chopra,Victoria Sung,Olivier Hermine,Ivan C. Moura +20 more
TL;DR: Observations suggest that ActRIIA ligand traps may have therapeutic relevance in β-thalassemia by suppressing the deleterious effects of GDF11, a cytokine which blocks terminal erythroid maturation through an autocrine amplification loop involving oxidative stress and α-globin precipitation.
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The dual mTORC1 and mTORC2 inhibitor AZD8055 has anti-tumor activity in acute myeloid leukemia
Lise Willems,Nicolas Chapuis,Nicolas Chapuis,Alexandre Puissant,Thiago Trovati Maciel,Alexa S. Green,Alexa S. Green,Nathalie Jacque,Nathalie Jacque,Christine Vignon,Sophie Park,Sophie Park,Sylvie Guichard,Olivier Herault,Aurélie Fricot,Olivier Hermine,Ivan C. Moura,Patrick Auberger,Norbert Ifrah,Francois Dreyfus,Dominique Bonnet,Catherine Lacombe,Catherine Lacombe,Patrick Mayeux,Patrick Mayeux,Didier Bouscary,Jerome Tamburini,Jerome Tamburini +27 more
TL;DR: AZD8055 decreased AML blast cell proliferation and cell cycle progression, reduced the clonogenic growth of leukemic progenitors and induced caspase-dependent apoptosis inLeukemic cells but not in normal immature CD34+ cells, and induced autophagy, which may be either protective or cell death inducing, depending on concentration.
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Interactions Among Secretory Immunoglobulin A, CD71, and Transglutaminase-2 Affect Permeability of Intestinal Epithelial Cells to Gliadin Peptides
Corinne Lebreton,Sandrine Ménard,Juliette Abed,Ivan C. Moura,Rosanna Coppo,Christophe Dugave,Renato C. Monteiro,Aurélie Fricot,Meriem Garfa Traore,Martin Griffin,Christophe Cellier,Georgia Malamut,Nadine Cerf-Bensussan,Martine Heyman +13 more
TL;DR: Upon binding to apical CD71, SIgA (with or without gliadin peptides) enters a recycling pathway and avoids lysosomal degradation; this process allows apical-basal transcytosis of bound peptides.
Journal ArticleDOI
Hidden biomass of intact malaria parasites in the human spleen
Steven Kho,Labibah Qotrunnada,Leo Leonardo,Benediktus Andries,Putu A. I. Wardani,Aurélie Fricot,Benoit Henry,David Hardy,Nur I. Margyaningsih,Dwi Apriyanti,Agatha M. Puspitasari,Pak Prayoga,Leily Trianty,Enny Kenangalem,Fabrice Chrétien,Innocent Safeukui,Hernando A. del Portillo,Carmen Fernandez-Becerra,Elamaran Meibalan,Matthias Marti,Ric N. Price,Tonia Woodberry,Papa Alioune Ndour,Bruce Russell,Tsin W. Yeo,Gabriela Minigo,Rintis Noviyanti,Jeanne Rini Poespoprodjo,Nurjati Chairani Siregar,Pierre Buffet,Nicholas M. Anstey +30 more
TL;DR: In this paper, patients living in a malaria-endemic area underwent trauma-related splenectomy, and were naturally infected with Plasmodium falconiformis infection.
Journal ArticleDOI
Polymeric IgA1 controls erythroblast proliferation and accelerates erythropoiesis recovery in anemia
Séverine Coulon,Michael Dussiot,Michael Dussiot,Michael Dussiot,Damien Grapton,Damien Grapton,Damien Grapton,Thiago Trovati Maciel,Thiago Trovati Maciel,Pamella Huey Mei Wang,Pamella Huey Mei Wang,Céline Callens,Meetu Kaushik Tiwari,Meetu Kaushik Tiwari,Saurabh Agarwal,Saurabh Agarwal,Aurélie Fricot,Julie Vandekerckhove,Houda Tamouza,Houda Tamouza,Yael Zermati,Jean-Antoine Ribeil,Jean-Antoine Ribeil,Kamel Djedaini,Zeliha Oruc,Virginie Pascal,Geneviève Courtois,Bertrand Arnulf,Marie-Alexandra Alyanakian,Marie-Alexandra Alyanakian,Patrick Mayeux,Patrick Mayeux,Tomas Leanderson,Marc Benhamou,Marc Benhamou,Michel Cogné,Renato C. Monteiro,Renato C. Monteiro,Olivier Hermine,Olivier Hermine,Ivan C. Moura,Ivan C. Moura +41 more
TL;DR: It is shown that, when cultured with Epo at suboptimal concentrations, the growth and clonogenic potential of erythroblasts was rescued by transferrin receptor 1 (TfR1)-bound polymeric IgA1 (pIgA1).