J
Jennifer L. Slack
Researcher at Amgen
Publications - 22
Citations - 8352
Jennifer L. Slack is an academic researcher from Amgen. The author has contributed to research in topics: Receptor & Cytokine. The author has an hindex of 17, co-authored 22 publications receiving 8078 citations. Previous affiliations of Jennifer L. Slack include University of North Carolina at Chapel Hill.
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Journal ArticleDOI
A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
Roy A. Black,Charles Rauch,Carl J. Kozlosky,Jacques J. Peschon,Jennifer L. Slack,Martin F. Wolfson,Beverly J. Castner,Kim L. Stocking,Pranitha Reddy,Subhashini Srinivasan,Nicole Nelson,Norman Boiani,Kenneth A. Schooley,Mary Gerhart,Raymond Davis,Jeffrey N. Fitzner,Richard S. Johnson,Raymond J. Paxton,Carl J. March,Douglas P. Cerretti +19 more
TL;DR: The results should facilitate the development of therapeutically useful inhibitors of TNF-α release, and they indicate that an important function of adamalysins may be to shed cell-surface proteins.
Journal ArticleDOI
An Essential Role for Ectodomain Shedding in Mammalian Development
Jacques J. Peschon,Jennifer L. Slack,Pranitha Reddy,Kim L. Stocking,Susan W. Sunnarborg,David C. Lee,William E. Russell,Beverly J. Castner,Richard S. Johnson,Jeffrey N. Fitzner,Rogely W. Boyce,Nicole Nelson,Carl J. Kozlosky,Martin F. Wolfson,Charles Rauch,Douglas P. Cerretti,Raymond J. Paxton,Carl J. March,Roy A. Black +18 more
TL;DR: The phenotype of mice lacking TACE suggests an essential role for soluble TGFalpha in normal development and emphasizes the importance of protein ectodomain shedding in vivo.
Journal ArticleDOI
Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor
Joseph D. Buxbaum,Kang-Nian Liu,Yuxia Luo,Jennifer L. Slack,Kim L. Stocking,Jacques J. Peschon,Richard S. Johnson,Beverly J. Castner,Douglas P. Cerretti,Roy A. Black +9 more
TL;DR: It is demonstrated that TACE (tumor necrosis factor α converting enzyme), a member of the ADAM family (a disintegrinand metalloprotease-family) of proteases, plays a central role in regulated α-cleavage of APP.
Journal ArticleDOI
Interleukin 1 signaling occurs exclusively via the type I receptor.
John E. Sims,M A Gayle,Jennifer L. Slack,Mark R. Alderson,T A Bird,J G Giri,Francesco Colotta,Fabio Re,Alberto Mantovani,K Shanebeck +9 more
TL;DR: It is concluded that a very small number of type I receptors is sufficient to mediate all of the actions of IL-1 which are examined here and that the function of the type II receptor may not be to transduce signals.
Journal ArticleDOI
Functional Analysis of the Domain Structure of Tumor Necrosis Factor-α Converting Enzyme
Pranhitha Reddy,Jennifer L. Slack,Raymond J. Davis,Douglas P. Cerretti,Carl J. Kozlosky,Rebecca A. Blanton,Donna Shows,Jacques J. Peschon,Roy A. Black +8 more
TL;DR: It is found that TACE must be expressed with its membrane-anchoring domain for phorbol ester-stimulated shedding of TNF, p75 TNFR, and IL-1R-II, but that the cytoplasmic domain is not required for the shedding of these substrates.