Evidence That Tumor Necrosis Factor α Converting Enzyme Is Involved in Regulated α-Secretase Cleavage of the Alzheimer Amyloid Protein Precursor
Joseph D. Buxbaum,Kang-Nian Liu,Yuxia Luo,Jennifer L. Slack,Kim L. Stocking,Jacques J. Peschon,Richard S. Johnson,Beverly J. Castner,Douglas P. Cerretti,Roy A. Black +9 more
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TLDR
It is demonstrated that TACE (tumor necrosis factor α converting enzyme), a member of the ADAM family (a disintegrinand metalloprotease-family) of proteases, plays a central role in regulated α-cleavage of APP.About:
This article is published in Journal of Biological Chemistry.The article was published on 1998-10-23 and is currently open access. It has received 912 citations till now. The article focuses on the topics: Alpha secretase & Amyloid precursor protein secretase.read more
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Journal ArticleDOI
Inflammation and Alzheimer's disease.
Haruhiko Akiyama,Steven W. Barger,Scott R. Barnum,B Bradt,Jürgen Bauer,Greg M. Cole,Neil R. Cooper,Piet Eikelenboom,Mark R. Emmerling,Bernd L. Fiebich,Caleb E. Finch,Sally A. Frautschy,W. S. T. Griffin,Harald Hampel,Michael Hüll,Gary E. Landreth,Lih-Fen Lue,Robert E. Mrak,Ian R. A. Mackenzie,Patrick L. McGeer,M K O'Banion,Joel S. Pachter,Giulio Maria Pasinetti,C Plata-Salaman,Joseph G. Rogers,Russell E. Rydel,Yueyang Shen,Wolfgang J. Streit,Ronald Strohmeyer,I Tooyoma,F L van Muiswinkel,R. Veerhuis,David G. Walker,Scott D. Webster,Beatrice Hauss–Wegrzyniak,Gary L. Wenk,Tony Wyss-Coray +36 more
TL;DR: By better understanding AD inflammatory and immunoregulatory processes, it should be possible to develop anti-inflammatory approaches that may not cure AD but will likely help slow the progression or delay the onset of this devastating disorder.
Journal ArticleDOI
Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
Robert Vassar,Brian D. Bennett,Safura Babu-Khan,Steve Kahn,Elizabeth A. Mendiaz,Paul Denis,David B. Teplow,Sandra Ross,Patricia Amarante,Richard Loeloff,Yi Luo,Seth Fisher,Janis Fuller,Steven P. Edenson,Jackson Lile,Mark A. Jarosinski,Anja Leona Biere,Eileen Curran,Teresa L. Burgess,Jean Claude Louis,Frank H. Collins,James J. S. Treanor,Gary Rogers,Martin Citron +23 more
TL;DR: Overexpression of a transmembrane aspartic protease, termed BACE (for beta-site APP-cleaving enzyme) increased the amount of beta-secretase cleavage products, and these were cleaved exactly and only at known beta- secretase positions.
Journal ArticleDOI
Pathways towards and away from Alzheimer's disease
TL;DR: Rapid progress towards understanding the cellular and molecular alterations that are responsible for the neuron's demise may soon help in developing effective preventative and therapeutic strategies in Alzheimer's disease.
Journal ArticleDOI
Translating cell biology into therapeutic advances in Alzheimer's disease
TL;DR: Progress in understanding this cascade has helped to identify specific therapeutic targets and provides a model for elucidating other neurodegenerative disorders.
Journal ArticleDOI
Regulated Intramembrane Proteolysis: A Control Mechanism Conserved from Bacteria to Humans
TL;DR: This research is supported by grants from the National Institutes of Health (HL20948) and the Perot Family Foundation.
References
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Journal ArticleDOI
A metalloproteinase disintegrin that releases tumour-necrosis factor-α from cells
Roy A. Black,Charles Rauch,Carl J. Kozlosky,Jacques J. Peschon,Jennifer L. Slack,Martin F. Wolfson,Beverly J. Castner,Kim L. Stocking,Pranitha Reddy,Subhashini Srinivasan,Nicole Nelson,Norman Boiani,Kenneth A. Schooley,Mary Gerhart,Raymond Davis,Jeffrey N. Fitzner,Richard S. Johnson,Raymond J. Paxton,Carl J. March,Douglas P. Cerretti +19 more
TL;DR: The results should facilitate the development of therapeutically useful inhibitors of TNF-α release, and they indicate that an important function of adamalysins may be to shed cell-surface proteins.
Journal ArticleDOI
Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha.
Marcia L. Moss,S.-L. Catherine Jin,Marcos E. Milla,William Burkhart,H. Luke Carter,Wen-Ji Chen,William C. Clay,John R. Didsbury,Daniel F. Hassler,Christine R. Hoffman,Thomas A. Kost,Millard H. Lambert,M. Anthony Leesnitzer,Philip McCauley,Gerard McGeehan,Justin L. Mitchell,Mary Pat Moyer,Gregory Pahel,Warren J. Rocque,Laurie K. Overton,Frank J Schoenen,Theresa D. Seaton,Jui-Lan Su,Janet Warner,Derril H. Willard,J. David Becherer +25 more
TL;DR: The expression of recombinant TACE results in the production of functional enzyme that correctly processes precursor TNF-α to the mature form, and provides a readily available source of enzyme to help in the search for new anti-inflammatory agents that target the final processing stage of T NF-α production.
Journal ArticleDOI
Cleavage of amyloid beta peptide during constitutive processing of its precursor
Frederick Esch,Pamela S. Keim,Eric C. Beattie,Russell W. Blacher,Alan R. Culwell,Tilman Oltersdorf,Donald McClure,Pamela J. Ward +7 more
TL;DR: Direct protein structural analyses showed that constitutive processing in human embryonic kidney 293 cells cleaves APP in the interior of the A Beta P, thus preventing A beta P deposition.
Journal ArticleDOI
Release of Alzheimer Amyloid Precursor Derivatives Stimulated by Activation of Muscarinic Acetylcholine Receptors
TL;DR: Stimulation of m1 and m3 receptor subtypes with carbachol increased the basal release of APP derivatives within minutes of treatment, indicating that preexisting APP is released in response to receptor activation and protein kinases mediate neurotransmitter receptor-controlled APP processing.
Journal ArticleDOI
Amyloid beta-protein and the genetics of Alzheimer's disease.
TL;DR: The effort to decipher the mechanism of Alzheimer's disease has attracted the interest of investigators from diverse biological disciplines, including biochemistry, cell biology, molecular genetics, neuroscience, and structural biology, and it is increasingly likely that AD will become a premier example of the successful application of biological chemistry to the identification of rational therapeutic targets in a major human disease.
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Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE.
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