J
Jeremiah J. Faith
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 112
Citations - 21045
Jeremiah J. Faith is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Medicine & Gut flora. The author has an hindex of 35, co-authored 85 publications receiving 16852 citations. Previous affiliations of Jeremiah J. Faith include Cold Spring Harbor Laboratory & Boston University.
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Journal ArticleDOI
The Role of the Gut Microbiota in the Metabolism of Polyphenols as Characterized by Gnotobiotic Mice.
Giulio Maria Pasinetti,Giulio Maria Pasinetti,Risham Singh,Susan Westfall,Francis J. Herman,Jeremiah J. Faith,Lap Ho +6 more
TL;DR: It is proposed that leveraging the gut microbial ecosystem to generate brain targeted bioactive metabolites from dietary polyphenols can attenuate lifestyle risk factors and promote resilience against age-related cognitive decline.
Journal ArticleDOI
Evolution of base-substitution gradients in primate mitochondrial genomes
Sameer Z. Raina,Jeremiah J. Faith,Jeremiah J. Faith,Todd R. Disotell,Hervé Seligmann,Caro-Beth Stewart,David D. Pollock +6 more
TL;DR: A methodology was developed to evaluate the posterior probability densities of the response parameter space, and used likelihood ratio tests and mixture models with different numbers of classes to determine whether groups of genomes have evolved in a similar fashion.
Journal ArticleDOI
The gut microbiota composition affects dietary polyphenols-mediated cognitive resilience in mice by modulating the bioavailability of phenolic acids.
Tal Frolinger,Steven Sims,Chad C. Smith,Jun Wang,Haoxiang Cheng,Jeremiah J. Faith,Lap Ho,Ke Hao,Giulio Maria Pasinetti,Giulio Maria Pasinetti +9 more
TL;DR: The gut microbiota composition significantly affects the bioavailability of phenolic acids that drive the dietary polyphenols’ cognitive resilience property, and the beneficial effect of BDPP on memory in SD is attenuated by ABX-induced dysbiosis.
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Heterogeneity in gut microbiota drive polyphenol metabolism that influences α-synuclein misfolding and toxicity.
Lap Ho,Danyue Zhao,Kenjiro Ono,Kai Ruan,Ilaria Mogno,Mayumi Tsuji,Eileen Carry,Justin Brathwaite,Steven Sims,Tal Frolinger,Susan Westfall,Paolo Mazzola,Qingli Wu,Ke Hao,Thomas E. Lloyd,James E. Simon,Jeremiah J. Faith,Giulio Maria Pasinetti,Giulio Maria Pasinetti +18 more
TL;DR: The findings provide the basis for future developments of probiotic, prebiotic, or synbiotic approaches for modulating the onset and/ or progression of α-synucleinopathies and other neurological disorders involving protein misfolding and/or inflammation.
Journal ArticleDOI
Defined microbiota transplant restores Th17/RORγt+ regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas
Graham J. Britton,Eduardo J. Contijoch,Matthew P. Spindler,Varun Aggarwala,Belgin Dogan,Gerold Bongers,Lani San Mateo,Andrew Baltus,Anuk Das,Dirk Gevers,Thomas J. Borody,Nadeem O. Kaakoush,Michael A. Kamm,Michael A. Kamm,Hazel M. Mitchell,Sudarshan Paramsothy,Sudarshan Paramsothy,Jose C. Clemente,Jean-Frederic Colombel,Kenneth W. Simpson,Marla Dubinsky,Ari Grinspan,Jeremiah J. Faith +22 more
TL;DR: It is found that the mouse gut immune system is changed by microbiota transplants, becoming broadly less inflammatory and protecting mice from colitis, and increases in the density of microbiota following transplant may be antiinflammatory.