J
Jeremiah J. Faith
Researcher at Icahn School of Medicine at Mount Sinai
Publications - 112
Citations - 21045
Jeremiah J. Faith is an academic researcher from Icahn School of Medicine at Mount Sinai. The author has contributed to research in topics: Medicine & Gut flora. The author has an hindex of 35, co-authored 85 publications receiving 16852 citations. Previous affiliations of Jeremiah J. Faith include Cold Spring Harbor Laboratory & Boston University.
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Defined microbiota transplant restores Th17/RORγt+ regulatory T cell balance in mice colonized with inflammatory bowel disease microbiotas
Graham J. Britton,Eduardo J. Contijoch,Matthew P. Spindler,Varun Aggarwala,Gerold Bongers,Lani San Mateo,Andrew Baltus,Anuk Das,Dirk Gevers,Thomas J. Borody,Nadeem O. Kaakoush,Michael A. Kamm,Hazel M. Mitchell,Sudarshan Paramsothy,Jose C. Clemente,Jean-Frederic Colombel,Marla Dubinsky,Ari Grinspan,Jeremiah J. Faith +18 more
TL;DR: Using gnotobiotic mice to model microbiota manipulations in the context of microbiotas from humans with inflammatory bowel disease, a specific strain is identified that potently induces Th17 cells in mice colonized with a microbiota from a donor with Crohn’s disease.
Posted ContentDOI
Diet Modifies Colonic Microbiota and CD4+ T cell Repertoire to Trigger Flares in a Novel Model of Colitis Induced by IL-23
Lili Chen,Zhengxiang He,Alina Iuga,Sebastião Nunes Martins Filho,Jeremiah J. Faith,Jose C. Clemente,Madhura Deshpande,Anitha D. Jayaprakash,Jean-Frederic Colombel,Juan J. Lafaille,Ravi Sachidanandam,Glaucia C. Furtado,Sergio A. Lira +12 more
TL;DR: A critical role is revealed for IL-23 in generation of a CD4+ T cell population in mice that is sensitive to a modification of intestinal bacterial flora subsequent to a dietary manipulation, which may contribute to the onset and progression of IBD.
Posted ContentDOI
Human Microbial Transplant Restores T Cell Cytotoxicity and Anti-Tumor Response to PD-L1 Blockade in Gnotobiotic Mice
Joshua N. Borgerding,Joan Shang,Graham J. Britton,Hélène Salmon,Hélène Salmon,Camille Bigenwald,Camille Bigenwald,Barbara Maier,Samuel R. Rose,Ilaria Mogno,Alice O. Kamphorst,Miriam Merad,Jeremiah J. Faith +12 more
TL;DR: The results demonstrate inhibitory roles for the microbiota in checkpoint blockade and reveal the potential for microbiota transplant and TNF blockade to overcome microbiota-mediated resistance.
Posted ContentDOI
Strain population structure varies widely across bacterial species and predicts strain colonization in unrelated individuals
Jeremiah J. Faith,Alice Chen-Liaw,Varun Aggarwala,Nadeem O. Kaakoush,Thomas J. Borody,Hazel M. Mitchell,Michael A. Kamm,Michael A. Kamm,Sudarshan Paramsothy,Sudarshan Paramsothy,Evan S. Snitkin,Ilaria Mogno +11 more
TL;DR: Strain population sizes ranged from tens to over one-hundred thousand per species, and prevalent strains in common gut microbiota species with small population sizes were the most likely to be harbored in two or more unrelated individuals.
Journal ArticleDOI
The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals
Guillaume Butler-Laporte,Edgar Gonzalez-Kozlova,Chen-Yang Su,Sirui Zhou,Tomoko Nakanishi,Elsa Brunet-Ratnasingham,David R. Morrison,Lætitia Laurent,Jonathan Afilalo,Marc Afilalo,D. Henry,Yiheng Chen,Julia Carrasco-Zanini,Yossi Farjoun,Maik Pietzner,N. A. Kimchi,Zaman Afrasiabi,Nardin Rezk,M. Bouab,Louis Petitjean,Charlotte Guzman,Xiaoqing Xue,Chris Tselios,Branka Vulesevic,Olumide Adeleye,Tala Abdullah,Noor Almamlouk,Yara Moussa,Chantal DeLuca,N Duggan,Erwin Schurr,Nathalie Brassard,Madeleine Durand,Diane Marie Del Valle,Ryan F. Thompson,Mario A. Cedillo,Eric E. Schadt,Kai Nie,Nicole W. Simons,Konstantinos Mouskas,Nicolas Zaki,Hui Xie,Kimberly Argueta,Ieisha Scott,Charuta Agashe,Priyal Agrawal,Alara Akyatan,Kasey Alesso-Carra,Eziwoma Alibo,Kelvin Alvarez,Angelo Amabile,Carmen Argmann,S. Ascolillo,Rasheed A. Bailey,Craig Batchelor,Aviva G. Beckmann,Priya Begani,Jessica Le Berichel,Dusan Bogunovic,Swaroop Bose,Cansu Cimen Bozkus,Paloma Bravo,Mark Buckup,Larissa R. Burka,Sharlene Calorossi,Lena Cambron,Guillermo Carbonell,G. Carrara,Christie Chang,Serena Chia-Jen Chang,Steven T. Chen,Esther Cheng,Jonathan Chien,Mashkura Chowdhury,Jonathan H. Chung,Phillip H. Comella,Dana Cosgrove,Francesca Cossarini,Liam Cotter,Arpit Dave,Travis Dawson,Bheesham Dayal,Maxime Dhainaut,R. Dornfeld,Katie Dul,Melody K. Eaton,N. Eber,Cordelia Elaiho,Ethan Ellis,Frank Fabris,Jeremiah J. Faith,Dominique Falci,Susie Feng,Brian Kenneth Fennessy,Marie Correa-Fernandes,N O Fishman,Nancy Francoeur,Sandeep Gangadharan,Daniel Geanon,Bruce D. Gelb,Benjamin S. Glicksberg,Joanna Grabowska,Gavin Gyimesi,Maha El Hamdani,Diana Z. Handler,Jocelyn Harris,Matthew Hartnett,Sandra Hatem,Manon Herbinet,Elva Herrera,Arielle Hochman,Gabriel E. Hoffman,J.L. Hook,L Horta,Etienne Humblin,Suraj K. Jaladanki,Hajra Jamal,Jessica S. Johnson,Gurpawan Kang,Neha Karekar,Subha Karim,Geoffrey Kelly,Jong Kim,Seunghee Kim-Schulze,Edgar Ernesto Gonzalez Kozlova,Arvind Kumar,Josefina Lacunza,Alona Lansky,Dannielle Lebovitch,Brian T. Lee,Grace Lee,Gyu Ho Lee,Jacky Hoong Lee,John Leech,Lauren Lepow,Michael Leventhal,Lora Liharska,Katherine E. Lindblad,Alexandra E. Livanos,Bojan Losic,Rosalie Machado,Kent Madrid,Zafar Mahmood,Kelcey Mar,Thomas U. Marron,Glenn Martin,Robert Marvin,Shrisha Maskey,Paul Matthews,Katherine Meckel,Saurabh Mehandru,Cynthia R. Mercedes,Elyze Merzier,Dara Meyer,Gurkan Mollaoglu,Sarah Morris,Emily Moya,Naa-akomaah Yeboah,Girish N. Nadkarni,Marjorie Nisenholtz,George Ofori-Amanfo,Kenan Onel,Merouane Ounadjela,Manishkumar Dasharathalal Patel,V. Patel,Cassandra Pruitt,Adeeb Rahman,S. Rathi,Jamie L Redes,Ivan Reyes-Torres,Alcina A. Rodrigues,Alfonso Rodriguez,Vladimir Roudko,Panagiotis Roussos,Evelyn Henao Ruiz,Pearl Scalzo,Robert Sebra,Hardik Shah,Mark M. Shervey,Pedro Silva,Melissa Smith,Alessandra Soares Schanoski,Juan C. Diaz Soto,Shwetha Hara Sridhar,Stacey Brown,Hiyab Stefanos,Meghan Straw,Robert Sweeney,Alexandra Tabachnikova,Collin D. Teague,Manying Tin,Kevin Tuballes,Scott R. Tyler,Bhaskar Upadhyaya,Akhil Vaid,Verena van der Heide,Natalie Vaninov,Konstantinos Vlachos,Daniel Wacker,Laura Walker,Hadley Walsh,Wenhui Wang,Bo Wang,Christian Matthias Wilk,Lillian Wilkins,Karen Wilson,Jessica A. Wilson,Lifei Xue,Nancy Yi,Ying-Chih Wang,Mahlet Yishak,S. Young,Alex Eunkyeong Yu,Nina Zaks,Ren-Yuan Zha,Celia M. T. Greenwood,CJ Paterson,Michael A Hinterberg,Claudia Langenberg,Vincenzo Forgetta,Vincent Mooser,Noam D. Beckmann,Ephraim Kenigsberg,Alexander W. Charney,Miriam Merad,Daniel Kaufmann,Sacha Gnjatic,J. Brent Richards +227 more
TL;DR: In this article , the authors measured 147 immune-related proteins during acute COVID-19 to investigate the differences in outcomes between sexes between severe cases and controls, adjusting for age and sex.