Ilaria Mogno

TL;DR: The compendium of expression data compiled in this study, coupled with RegulonDB, provides a valuable model system for further improvement of network inference algorithms using experimental data.

TL;DR: In P.’aeruginosa, the GacS/GacA system transduces the regulatory signals to downstream genes exclusively by directly controlling the expression of only two genes rsmY and rsmZ, highlighting the importance of post‐transcriptional mechanisms involving sRNAs in controlling gene expression during bacterial adaptation to different environments.

TL;DR: An impact on intestinal Th17 and ROR&ggr;t+ regulatory T cell compartments emerges as a unifying feature of IBD microbiotas, suggesting a general mechanism for microbial contribution to IBD pathogenesis.

TL;DR: It is shown that the protozoan Tritrichomonas musculis activates the host epithelial inflammasome to induce IL-18 release, which increases mucosal host defenses at the cost of an increased risk of inflammatory disease.

TL;DR: Understanding the interplay between microbiota and disease in terms of microbiota density, host carrying capacity, and microbiota fitness provide new insights into microbiome structure and microbiome targeted therapeutics.