J
Jerzy Sadowski
Researcher at Jagiellonian University Medical College
Publications - 286
Citations - 9986
Jerzy Sadowski is an academic researcher from Jagiellonian University Medical College. The author has contributed to research in topics: Aortic valve replacement & Aortic valve. The author has an hindex of 31, co-authored 280 publications receiving 9235 citations. Previous affiliations of Jerzy Sadowski include University of Maryland, Baltimore & University of Oxford.
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Renal sympathetic denervation in patients with treatment-resistant hypertension (The Symplicity HTN-2 Trial): A randomised controlled trial
Murray D. Esler,Henry Krum,Paul A. Sobotka,Markus P. Schlaich,Roland E. Schmieder,Michael Böhm,Felix Mahfoud,Horst Sievert,Nina Wunderlich,Lars Christian Rump,Oliver Vonend,Michael Uder,Mel Lobo,Mark J. Caulfield,Andrejs Erglis,Michel Azizi,Marc Sapoval,S. Thambar,Alexandre Persu,Jean Renkin,Heribert Schunkert,Joachim Weil,Uta C. Hoppe,Tony Walton,Dierk Scheinert,Thomas Binder,Andrzej Januszewicz,Adam Witkowski,Luis M. Ruilope,Robert Whitbourn,Heike Bruck,Mark Downes,Thomas F. Lüscher,Alan G. Jardine,Mark Webster,Thomas Zeller,Jerzy Sadowski,Krzysztof Bartus,Craig A. Straley,Neil C. Barman,David P. Lee,Ronald M. Witteles,Vivek Bhalla,Joseph M. Massaro +43 more
TL;DR: Catheter-based renal denervation can safely be used to substantially reduce blood pressure in treatment-resistant hypertensive patients and should be continued, according to the authors.
Journal ArticleDOI
Catheter-based renal sympathetic denervation for resistant hypertension: a multicentre safety and proof-of-principle cohort study
Henry Krum,Markus P. Schlaich,Robert Whitbourn,Paul A. Sobotka,Jerzy Sadowski,Krzysztof Bartus,Bogusław Kapelak,Anthony Walton,Horst Sievert,S. Thambar,William T. Abraham,Murray D. Esler +11 more
TL;DR: In this article, a proof-of-principle trial of therapeutic renal sympathetic denervation in patients with resistant hypertension (i.e., systolic blood pressure ≥160 mm/hg on three or more antihypertensive medications, including a diuretic) was conducted to assess safety and blood-pressure reduction effectiveness.
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Mechanisms of Increased Vascular Superoxide Production in Human Diabetes Mellitus Role of NAD(P)H Oxidase and Endothelial Nitric Oxide Synthase
Tomasz J. Guzik,Shafi Mussa,Daniela Gastaldi,Jerzy Sadowski,Chandi Ratnatunga,Ravi Pillai,Keith M. Channon +6 more
TL;DR: These observations suggest important roles for NAD(P)H oxidases, endothelial NO synthase uncoupling, and protein kinase C signaling in mediating increased vascular superoxide production and endothelial dysfunction in human diabetes mellitus.
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Percutaneous Left Atrial Appendage Suture Ligation Using the LARIAT Device in Patients With Atrial Fibrillation: Initial Clinical Experience
Krzysztof Bartus,Frederick T. Han,Jacek Bednarek,Jacek Myć,Bogusław Kapelak,Jerzy Sadowski,Jacek Lelakowski,Stanislaw Bartus,Steven J. Yakubov,Randall J. Lee +9 more
TL;DR: LAA closure with the LARIAT device can be performed effectively with acceptably low access complications and periprocedural adverse events in this observational study.
Journal ArticleDOI
Coronary Artery Superoxide Production and Nox Isoform Expression in Human Coronary Artery Disease
Tomasz J. Guzik,Jerzy Sadowski,Bartłomiej Guzik,Andrew Jopek,Bogusław Kapelak,Piotr Przybyłowski,Karol Wierzbicki,Ryszard Korbut,David G. Harrison,Keith M. Channon +9 more
TL;DR: Increased expression and activity of NAD(P)H oxidase subunits and xanthine oxidase, in part mediated through angiotensin II and PKC-dependent pathways, are important mechanisms underlying increased oxidative stress in human coronary artery disease.