Jesse M. Damsker

TL;DR: Recent studies report overlapping as well as differential roles of these cells in tissue inflammation, which suggests the existence of a more complex relationship between these two effector T‐cell subsets than has hitherto been suspected.

TL;DR: Successful improvement of dystrophy independent of hormonal, growth, or immunosuppressive effects is demonstrated, indicating VBP15 merits clinical investigation for DMD and would benefit other chronic inflammatory diseases.

TL;DR: It is proposed that extracellular cyclophilins, via interaction with CD147, may contribute to the recruitment of leukocytes from the periphery into tissues during inflammatory responses, providing a novel mechanism whereby asthmatic lung inflammation may be reduced.

TL;DR: It is shown that activatd human T lymphocytes express elevated levels of CD147, compared with resting T cells and that these activated T cells migrate more readily to CypA than resting cells, suggesting that cyclophilin‐CD147 interactions will be most potent when leukocytes are in an activated state, for example, during inflammatory responses.

TL;DR: It is demonstrated that proinflammatory leucocytes, specifically neutrophils, monocytes and activated CD4+ T cells, lose their ability to migrate in response to cyclophilin A in vitro when treated with anti‐CD147 monoclonal antibody, suggesting that CD147–cyclophil in interactions might contribute to the pathogenesis of RA by promoting the recruitment of leucocyte into joint tissues.