J
Jia Z. Shen
Researcher at Discovery Institute
Publications - 15
Citations - 105
Jia Z. Shen is an academic researcher from Discovery Institute. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 2, co-authored 4 publications receiving 12 citations.
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Journal ArticleDOI
FBXO44 promotes DNA replication-coupled repetitive element silencing in cancer cells.
Jia Z. Shen,Zhixin Qiu,Qiulian Wu,Darren Finlay,Guillermina Garcia,Dahui Sun,Juha Rantala,William D. Barshop,Jennifer L. Hope,Ryan C. Gimple,Ryan C. Gimple,Olle Sangfelt,Linda M. Bradley,James A. Wohlschlegel,Jeremy N. Rich,Charles Spruck +15 more
TL;DR: In this paper, the authors identified FBXO44 as an essential repressor of repetitive elements (REs) in cancer cells and showed that their inhibition selectively induces DNA replication stress and viral mimicry.
Journal ArticleDOI
Ferroptosis in Rheumatoid Arthritis: A Potential Therapeutic Strategy
TL;DR: The common features between ferroptosis and the pathogenesis of rheumatoid arthritis (RA) are discussed, therapeutic applications of ferroPTosis regulators in preclinical and clinical research are evaluated, and critical issues worth paying attention to are raised.
Journal ArticleDOI
Transcription Elongation Machinery Is a Druggable Dependency and Potentiates Immunotherapy in Glioblastoma Stem Cells.
Zhixin Qiu,Linjie Zhao,Jia Z. Shen,Zhengyu Liang,Qiulian Wu,Kailin Yang,Lihua Min,Ryan C. Gimple,Qiyuan Yang,Shruti Bhargava,Chunyu Jin,Cheryl Kim,Denise Hinz,Deobrat Dixit,Jean A. Bernatchez,Briana C. Prager,Guoxin Zhang,Zhen Dong,Deguan Lv,Xujun Wang,Leo J.Y. Kim,Zhe Zhu,Katherine A. Jones,Ye Zheng,Xiuxing Wang,Jair L. Siqueira-Neto,Lukas Chavez,Xiang-Dong Fu,Charles Spruck,Jeremy N. Rich +29 more
TL;DR: In this paper, a large-scale CRISPR/Cas9 screening was conducted on GBM stem cells (GSCs) to identify the master regulators of GSC stemness, revealing an essential transcription state with increased RNA polymerase II-mediated transcription.
Journal ArticleDOI
Dihydrotanshinone I inhibits ovarian tumor growth by activating oxidative stress through Keap1-mediated Nrf2 ubiquitination degradation.
Chengtao Sun,Bing-Kai Han,Yufei Zhai,Huan Zhao,Xuan S Li,Jun Qian,Xiaolong Hao,Qun Liu,Jia Z. Shen,Guoyin Kai +9 more
TL;DR: Dihydrotanshinone I (DHT), a bioactive compound in Salvia miltiorrhiza, was reported to exhibit cytotoxicity against various malignancies as mentioned in this paper .
Journal ArticleDOI
Targeting EYA2 tyrosine phosphatase activity in glioblastoma stem cells induces mitotic catastrophe
Guoxin Zhang,Zhen Dong,Ryan C. Gimple,Ryan C. Gimple,Arthur Wolin,Qiulian Wu,Zhixin Qiu,Lisa M Wood,Jia Z. Shen,Li Jiang,Linjie Zhao,Deguan Lv,Briana C. Prager,Briana C. Prager,Leo J.Y. Kim,Leo J.Y. Kim,Xiuxing Wang,Lingdi Zhang,Ryan L Anderson,Jeffrey K. Moore,Shideng Bao,Thomas H. Keller,Grace Lin,CongBao Kang,Petra Hamerlik,Rui Zhao,Heide L. Ford,Jeremy N. Rich,Jeremy N. Rich +28 more
TL;DR: In this paper, the EYA2 tyrosine (Tyr) phosphatase activity was found to be essential for proper mitotic spindle assembly and survival of GSCs.