J
Jian Ouyang
Researcher at Harvard University
Publications - 32
Citations - 2326
Jian Ouyang is an academic researcher from Harvard University. The author has contributed to research in topics: Medicine & DNA damage. The author has an hindex of 15, co-authored 21 publications receiving 1746 citations. Previous affiliations of Jian Ouyang include Tufts University & Rockefeller University.
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Journal ArticleDOI
RNA m6A methylation regulates the ultraviolet-induced DNA damage response.
Yang Xiang,Benoit Laurent,Benoit Laurent,Chih-Hung Hsu,Chih-Hung Hsu,Sigrid Nachtergaele,Zhike Lu,Zhike Lu,Wanqiang Sheng,Wanqiang Sheng,Chuanyun Xu,Chuanyun Xu,Hao Chen,Hao Chen,Jian Ouyang,Siqing Wang,Siqing Wang,Siqing Wang,Dominic Ling,Dominic Ling,Pang-Hung Hsu,Lee Zou,Ashwini Jambhekar,Ashwini Jambhekar,Chuan He,Chuan He,Yang Shi,Yang Shi +27 more
TL;DR: It is reported that methylation at the 6 position of adenosine (m6A) in RNA is rapidly and transiently induced at DNA damage sites in response to ultraviolet irradiation, uncovering a novel function for RNA m6A modification in the ultraviolet-induced DNA damage response.
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The Arabidopsis E3 SUMO ligase SIZ1 regulates plant growth and drought responses.
TL;DR: It is concluded that SIZ1 regulates Arabidopsis growth and that this SUMO E3 ligase plays a role in drought stress response likely through the regulation of gene expression.
Journal ArticleDOI
A SIRT1-LSD1 Corepressor Complex Regulates Notch Target Gene Expression and Development
Peter Mulligan,Fajun Yang,Luisa Di Stefano,Jun-Yuan Ji,Jian Ouyang,Joy L. Nishikawa,Debra Toiber,Madhura Kulkarni,Qun Wang,S. Hani Najafi-Shoushtari,Raul Mostoslavsky,Steven P. Gygi,Grace Gill,Nicholas J. Dyson,Anders M. Näär +14 more
TL;DR: A SIRT1 corepressor complex containing the histone H3K4 demethylase LSD1/KDM1A and several other LSD1-associated proteins is described, offering new insights into conserved mechanisms of epigenetic gene repression and regulation of development by Sirt1 in metazoans.
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The SUMO-specific protease SENP5 is required for cell division.
TL;DR: It is demonstrated here that SENP5, a previously uncharacterized Ulp1 homolog, has SUMO C-terminal hydrolase and SUMO isopeptidase activities and suggested that mechanisms involving both the catalytic and noncatalytic domains determine the distinct substrate specificities of the mammalian SUMO-specific proteases.
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Alternative Lengthening of Telomeres through Two Distinct Break-Induced Replication Pathways.
TL;DR: An assay is described to visualize ALT-mediated telomeric DNA synthesis in AlT-associated PML bodies (APBs) without DNA-damaging agents or replication inhibitors, suggesting that ALT occurs through a RAD52-dependent and a RAD 52-independent BIR pathway.