L
Luisa Di Stefano
Researcher at Harvard University
Publications - 19
Citations - 2538
Luisa Di Stefano is an academic researcher from Harvard University. The author has contributed to research in topics: Chromatin & Transcription factor. The author has an hindex of 13, co-authored 17 publications receiving 2338 citations. Previous affiliations of Luisa Di Stefano include European Institute of Oncology & Centre national de la recherche scientifique.
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Journal ArticleDOI
Identification of Functional Elements and Regulatory Circuits by Drosophila modENCODE
Sushmita Roy,Jason Ernst,Peter V. Kharchenko,Pouya Kheradpour,Nicolas Nègre,Matthew L. Eaton,Jane M. Landolin,Christopher A. Bristow,Lijia Ma,Michael F. Lin,Stefan Washietl,Bradley I. Arshinoff,Ferhat Ay,Patrick E. Meyer,Nicolas Robine,Nicole L. Washington,Luisa Di Stefano,Eugene Berezikov,Christopher D. Brown,Rogerio Candeias,Joseph W. Carlson,Adrian Carr,Irwin Jungreis,Daniel Marbach,Rachel Sealfon,Michael Y. Tolstorukov,Sebastian Will,Artyom A. Alekseyenko,Carlo G. Artieri,Benjamin W. Booth,Angela N. Brooks,Qi Dai,Carrie A. Davis,Michael O. Duff,X. Feng,Andrey A. Gorchakov,Tingting Gu,Jorja G. Henikoff,Philipp Kapranov,Renhua Li,Heather K. MacAlpine,John H. Malone,Aki Minoda,Jared T. Nordman,Katsutomo Okamura,Marc D. Perry,Sara K. Powell,Nicole C. Riddle,Akiko Sakai,Anastasia Samsonova,Jeremy E. Sandler,Yuri B. Schwartz,Noa Sher,Rebecca Spokony,David Sturgill,Marijke J. van Baren,Kenneth H. Wan,Li Yang,Charles Yu,Elise A. Feingold,Peter J. Good,Mark S. Guyer,Rebecca F. Lowdon,Kami Ahmad,Justen Andrews,Bonnie Berger,Steven E. Brenner,Michael R. Brent,Lucy Cherbas,Sarah C. R. Elgin,Thomas R. Gingeras,Robert L. Grossman,Roger A. Hoskins,Thomas C. Kaufman,W. J. Kent,Mitzi I. Kuroda,Terry L. Orr-Weaver,Norbert Perrimon,Vincenzo Pirrotta,James W. Posakony,Bing Ren,Steven Russell,Peter Cherbas,Brenton R. Graveley,Suzanna E. Lewis,Gos Micklem,Brian Oliver,Peter J. Park,Susan E. Celniker,Steven Henikoff,Gary H. Karpen,Eric C. Lai,David M. MacAlpine,Lincoln Stein,Kevin P. White,Manolis Kellis +95 more
TL;DR: The Drosophila Encyclopedia of DNA Elements (modENCODE) project as mentioned in this paper has been used to map transcripts, histone modifications, chromosomal proteins, transcription factors, replication proteins and intermediates, and nucleosome properties across a developmental time course and in multiple cell lines.
Journal ArticleDOI
E2F1 represses β-catenin transcription and is antagonized by both pRB and CDK8
Erick J. Morris,Jun-Yuan Ji,Fajun Yang,Luisa Di Stefano,Anabel Herr,Nam Sung Moon,Eun Jeong Kwon,Kevin M. Haigis,Anders M. Näär,Nicholas J. Dyson +9 more
TL;DR: By retaining RB1 and amplifying CDK8, colorectal tumour cells select conditions that collectively suppress E2F1 and enhance the activity of β-catenin.
Journal ArticleDOI
E2F7, a novel E2F featuring DP‐independent repression of a subset of E2F‐regulated genes
TL;DR: E2F7 is a unique repressor of a subset of E2F target genes whose products are required for cell cycle progression and inhibition of E 2F7 expression results in specific derepression of these promoters.
Journal ArticleDOI
A SIRT1-LSD1 Corepressor Complex Regulates Notch Target Gene Expression and Development
Peter Mulligan,Fajun Yang,Luisa Di Stefano,Jun-Yuan Ji,Jian Ouyang,Joy L. Nishikawa,Debra Toiber,Madhura Kulkarni,Qun Wang,S. Hani Najafi-Shoushtari,Raul Mostoslavsky,Steven P. Gygi,Grace Gill,Nicholas J. Dyson,Anders M. Näär +14 more
TL;DR: A SIRT1 corepressor complex containing the histone H3K4 demethylase LSD1/KDM1A and several other LSD1-associated proteins is described, offering new insights into conserved mechanisms of epigenetic gene repression and regulation of development by Sirt1 in metazoans.
Journal ArticleDOI
Characterization of E2F8, a novel E2F-like cell-cycle regulated repressor of E2F-activated transcription.
Jesper Christensen,Paul A. C. Cloos,Ulla Toftegaard,David Klinkenberg,Adrian P. Bracken,Emmanuelle Trinh,Mel Heeran,Luisa Di Stefano,Kristian Helin +8 more
TL;DR: Data suggest that E2F8 has an important role in turning of the expression of E 2F-target genes in the S-phase of the cell cycle, as well as a role for repressing E2f transcriptional activity.