J
Jian-Yi Wu
Researcher at Laboratory of Molecular Biology
Publications - 71
Citations - 2273
Jian-Yi Wu is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Survival rate & Cancer. The author has an hindex of 21, co-authored 70 publications receiving 1868 citations. Previous affiliations of Jian-Yi Wu include Shantou University.
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Journal ArticleDOI
Identification of genomic alterations in oesophageal squamous cell cancer
Yongmei Song,Lin Li,Yunwei Ou,Zhibo Gao,En-Min Li,Xiangchun Li,Weimin Zhang,Jiaqian Wang,Li-Yan Xu,Yong Zhou,Xiao-Juan Ma,Lingyan Liu,Zitong Zhao,Xuanlin Huang,Jing Fan,Lijia Dong,Gang Chen,Liying Ma,Jie Yang,Chen Longyun,Minghui He,Li Miao,Xuehan Zhuang,Kai Huang,Kunlong Qiu,Guangliang Yin,Guangwu Guo,Qiang Feng,Peishan Chen,Zhi-Yong Wu,Jian-Yi Wu,Ling Ma,Jinyang Zhao,Longhai Luo,Ming Fu,Bainan Xu,Bo Chen,Yingrui Li,Tong Tong,Mingrong Wang,Zhihua Liu,Dongxin Lin,Xiuqing Zhang,Huanming Yang,Jun Wang,Qimin Zhan +45 more
TL;DR: Genomic analyses suggest that ESCC and head and neck squamous cell carcinoma share some common pathogenic mechanisms, and ESCC development is associated with alcohol drinking, and novel biological markers and tumorigenic pathways that would greatly improve therapeutic strategies for ESCC are explored.
Journal ArticleDOI
Autoantibodies as Potential Biomarkers for the Early Detection of Esophageal Squamous Cell Carcinoma.
Yi-Wei Xu,Yu-Hui Peng,Bo Chen,Zhi-Yong Wu,Jian-Yi Wu,Jin-Hui Shen,Chun-Peng Zheng,Shao-Hong Wang,Hai-Peng Guo,En-Min Li,Li-Yan Xu +10 more
TL;DR: Measurement of an autoantibody response to multiple tumor-associated antigens in an optimized panel assay, to help discriminate early-stage ESCC patients from normal controls, may aid in early detection of ESCC.
Journal ArticleDOI
Involvement of CYR61 and CTGF in the Fascin-Mediated Proliferation and Invasiveness of Esophageal Squamous Cell Carcinomas Cells
Jian-Jun Xie,Li-Yan Xu,Jian-Yi Wu,Zhong-Ying Shen,Qing Zhao,Ze-Peng Du,Zhuo Lv,Wei Gu,Feng Pan,Xiu-E Xu,Dong Xie,Dong Xie,En-Min Li +12 more
TL;DR: It is proposed that fascin regulates the proliferation and invasiveness of ESCC cells by modulating the expression of CTGF and CYR61 via TGF-beta pathway.
Journal ArticleDOI
ATF3 functions as a novel tumor suppressor with prognostic significance in esophageal squamous cell carcinoma
Jian-Jun Xie,Yang-Min Xie,Bo Chen,Feng Pan,Jin-Cheng Guo,Qing Zhao,Jin-Hui Shen,Zhi-Yong Wu,Jian-Yi Wu,Li-Yan Xu,En-Min Li +10 more
TL;DR: A suppressed role for ATF3 is highlighted in ESCC and targeting ATF3 might be a potential therapeutic strategy, and it is shown that Cisplatin could restrain the invasion of ESCC cells by inducing the expression of ATF3 via P53 signaling.
Journal ArticleDOI
Association of mu-opioid receptor expression with lymph node metastasis in esophageal squamous cell carcinoma.
Ying-Li Zhang,Qing-Xia Xu,Lian-Di Liao,Xiu-E Xu,Jian-Yi Wu,Z.-Y. Wu,Jin-Hui Shen,En Min Li,Li Yan Xu +8 more
TL;DR: The results suggest that the cytoplasmic MOR1 may be a high-risk factor for lymph node metastasis of ESCC patients and hypothesize that MOR1 agonists used in ES CC patients should be prudent, and opioid receptor antagonists may be novel therapeutic drugs for ESCC customers.