Kunlong Qiu

TL;DR: Genomic analyses suggest that ESCC and head and neck squamous cell carcinoma share some common pathogenic mechanisms, and ESCC development is associated with alcohol drinking, and novel biological markers and tumorigenic pathways that would greatly improve therapeutic strategies for ESCC are explored.

TL;DR: A new method to identify fusion transcripts from paired-end RNA-Seq data by applying an improved partial exhaustion algorithm to construct a library of fusion junction sequences, and employs a series of filters to nominate high-confidence fusion transcripts.

TL;DR: This work integrated somatic mutational profiles and clinicopathologic information from 544 gastric cancer patients from previous genomic studies to identify significantly mutated genes (SMG) with prognostic relevance and a mutation signature predictive of patient survival in newly classified subtypes of Gastric cancer.

TL;DR: Results on simulated and real data from the 1000 Genomes Project and esophageal squamous cell carcinoma samples show that seeksv has higher efficiency and precision compared with other similar software in detecting SVs.

TL;DR: In this article, a method for detecting fusion transcripts in a sample to be analyzed is presented, which includes subjecting the sample containing a RNA transcriptome to paired-end sequencing, and aligning the first unmapped reads to annotated transcripts, to obtain second single-end mapped reads and second mismapped reads.