J
Jonathan H Tobias
Researcher at University of Bristol
Publications - 226
Citations - 9102
Jonathan H Tobias is an academic researcher from University of Bristol. The author has contributed to research in topics: Bone density & Bone mineral. The author has an hindex of 46, co-authored 226 publications receiving 7797 citations. Previous affiliations of Jonathan H Tobias include Medical Research Council & Royal National Hospital for Rheumatic Diseases.
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Journal ArticleDOI
An atlas of genetic influences on osteoporosis in humans and mice
John A. Morris,John P. Kemp,John P. Kemp,Scott E. Youlten,Laetitia Laurent,John G. Logan,Ryan C. Chai,Nicholas A. Vulpescu,Vincenzo Forgetta,Aaron Kleinman,Sindhu T. Mohanty,C. Marcelo Sergio,Julian M.W. Quinn,Loan Nguyen-Yamamoto,Aimee Lee Luco,Jinchu Vijay,Marie-Michelle Simon,Albena Pramatarova,Carolina Medina-Gomez,Katerina Trajanoska,Elena J. Ghirardello,Natalie C. Butterfield,Katharine F. Curry,Victoria D. Leitch,Penny C. Sparkes,Anne-Tounsia Adoum,Naila S. Mannan,Davide Komla-Ebri,Andrea S. Pollard,Hannah F. Dewhurst,Thomas A D Hassall,Michael-John G. Beltejar,Douglas J. Adams,Suzanne M. Vaillancourt,Stephen Kaptoge,Paul A. Baldock,Cyrus Cooper,Cyrus Cooper,Cyrus Cooper,Jonathan Reeve,Evangelia E. Ntzani,Evangelia E. Ntzani,Evangelos Evangelou,Evangelos Evangelou,Claes Ohlsson,David Karasik,Fernando Rivadeneira,Douglas P. Kiel,Jonathan H Tobias,Celia L Gregson,Nicholas C. Harvey,Nicholas C. Harvey,Elin Grundberg,Elin Grundberg,David Goltzman,David J. Adams,Christopher J. Lelliott,David A. Hinds,Cheryl L. Ackert-Bicknell,Yi-Hsiang Hsu,Matthew T. Maurano,Peter I. Croucher,Graham R. Williams,J. H. Duncan Bassett,David M. Evans,David M. Evans,J. Brent Richards +66 more
TL;DR: This genetic atlas provides evidence linking associated SNPs to causal genes, offers new insight into osteoporosis pathophysiology, and highlights opportunities for drug development.
Journal ArticleDOI
Whole-genome sequencing identifies EN1 as a determinant of bone density and fracture.
Hou-Feng Zheng,Vincenzo Forgetta,Yi-Hsiang Hsu,Yi-Hsiang Hsu,Karol Estrada,Alberto Roselló-Díez,Paul Leo,Chitra Lekha Dahia,Chitra Lekha Dahia,Kyung-Hyun Park-Min,Jonathan H Tobias,Charles Kooperberg,Aaron Kleinman,Unnur Styrkarsdottir,Ching-Ti Liu,Charlotta Uggla,Daniel S. Evans,Carrie M. Nielson,Klaudia Walter,Ulrika Pettersson-Kymmer,Shane A. McCarthy,Joel Eriksson,Tony Kwan,Mila Jhamai,Katerina Trajanoska,Yasin Memari,J L Min,Jie Huang,Petr Danecek,Beth Wilmot,Rui Li,Wen-Chi Chou,Lauren E. Mokry,Alireza Moayyeri,Alireza Moayyeri,Melina Claussnitzer,Chia-Ho Cheng,Warren A. Cheung,Carolina Medina-Gomez,Bing Ge,Shu Huang Chen,Kwangbom Choi,Ling Oei,James Fraser,Robert Kraaij,Matthew A. Hibbs,Matthew A. Hibbs,Celia L Gregson,Denis Paquette,Albert Hofman,Carl Wibom,Gregory J. Tranah,Mhairi Marshall,Brooke Gardiner,Katie Cremin,Paul L. Auer,Li Hsu,Susan M. Ring,Joyce Y. Tung,Gudmar Thorleifsson,A.W. Enneman,Natasja M. van Schoor,Lisette C. P. G. M. de Groot,Nathalie van der Velde,Beatrice Melin,John P. Kemp,John P. Kemp,Claus Christiansen,Adrian Sayers,Yanhua Zhou,Sophie Calderari,Jeroen van Rooij,Christopher S. Carlson,Ulrike Peters,Soizik Berlivet,Josée Dostie,André G. Uitterlinden,Stephen R. Williams,Charles R. Farber,Daniel Grinberg,Andrea Z. LaCroix,Jeffrey Haessler,Daniel I. Chasman,Franco Giulianini,Lynda M. Rose,Paul M. Ridker,John A. Eisman,John A. Eisman,John A. Eisman,Tuan V. Nguyen,Tuan V. Nguyen,Xavier Nogués,Xavier Nogués,Natalia Garcia-Giralt,Lenore Launer,V. Gudnason,Dan Mellström,Liesbeth Vandenput,Najaf Amin,Cornelia M. van Duijn,Magnus Karlsson,Östen Ljunggren,Olle Svensson,Göran Hallmans,François Rousseau,Sylvie Giroux,Johanne Bussiere,Pascal P. Arp,Fjorda Koromani,Richard L. Prince,Richard L. Prince,Joshua R. Lewis,Joshua R. Lewis,Bente L. Langdahl,A. Pernille Hermann,Jens Erik Beck Jensen,Stephen Kaptoge,Kay-Tee Khaw,Jonathan Reeve,Jonathan Reeve,Melissa M. Formosa,Angela Xuereb-Anastasi,Kristina Åkesson,Fiona E. McGuigan,Gaurav Garg,José M. Olmos,María T. Zarrabeitia,José A. Riancho,Stuart H. Ralston,Nerea Alonso,Xi Jiang,David Goltzman,Tomi Pastinen,Elin Grundberg,Dominique Gauguier,Eric S. Orwoll,David Karasik,George Davey-Smith,Albert V. Smith,Kristin Siggeirsdottir,Tamara B. Harris,M. Carola Zillikens,Joyce B. J. van Meurs,Unnur Thorsteinsdottir,Unnur Thorsteinsdottir,Matthew T. Maurano,Nicholas J. Timpson,Nicole Soranzo,Richard Durbin,Scott Wilson,Scott Wilson,Scott Wilson,Evangelia E. Ntzani,Evangelia E. Ntzani,Matthew A. Brown,Kari Stefansson,Kari Stefansson,David A. Hinds,Tim D. Spector,L. Adrienne Cupples,Claes Ohlsson,Celia M. T. Greenwood,Rebecca D. Jackson,David W. Rowe,Cynthia A. Loomis,David M. Evans,David M. Evans,Cheryl L. Ackert-Bicknell,Alexandra L. Joyner,Emma L. Duncan,Emma L. Duncan,Douglas P. Kiel,Fernando Rivadeneira,J. Brent Richards,J. Brent Richards +174 more
TL;DR: Evidence is provided that low‐frequency non‐coding variants have large effects on BMD and fracture, thereby providing rationale for whole‐genome sequencing and improved imputation reference panels to study the genetic architecture of complex traits and disease in the general population.
Journal ArticleDOI
A common variant of HMGA2 is associated with adult and childhood height in the general population
Michael N. Weedon,Guillaume Lettre,Guillaume Lettre,Rachel M. Freathy,Cecilia M. Lindgren,Cecilia M. Lindgren,Benjamin F. Voight,Benjamin F. Voight,John R. B. Perry,Katherine S. Elliott,Rachel Hackett,Candace Guiducci,Beverley M. Shields,Eleftheria Zeggini,Hana Lango,Valeriya Lyssenko,Valeriya Lyssenko,Nicholas J. Timpson,Nicholas J. Timpson,Noël P. Burtt,Nigel W. Rayner,Richa Saxena,Richa Saxena,Kristin Ardlie,Jonathan H Tobias,Andy R Ness,Susan M. Ring,Colin N. A. Palmer,Andrew D. Morris,Leena Peltonen,Leena Peltonen,Veikko Salomaa,George Davey Smith,Leif Groop,Leif Groop,Andrew T. Hattersley,Mark I. McCarthy,Mark I. McCarthy,Joel N. Hirschhorn,Joel N. Hirschhorn,Joel N. Hirschhorn,Timothy M. Frayling +41 more
TL;DR: There are few examples of common genetic variants reproducibly associated with human quantitativetraits; these results represent, to the authors' knowledge, the first consistently replicated association with adult and childhood height.
Journal ArticleDOI
Identification of 153 new loci associated with heel bone mineral density and functional involvement of GPC6 in osteoporosis
John P. Kemp,John P. Kemp,John A. Morris,Carolina Medina-Gomez,Vincenzo Forgetta,Nicole M. Warrington,Nicole M. Warrington,Scott E. Youlten,Scott E. Youlten,Jie Zheng,Celia L Gregson,Elin Grundberg,Katerina Trajanoska,John G. Logan,Andrea S. Pollard,Penny C. Sparkes,Elena J. Ghirardello,Rebecca Allen,Victoria D. Leitch,Natalie C. Butterfield,Davide Komla-Ebri,Anne-Tounsia Adoum,Katharine F. Curry,Jacqueline K. White,Fiona Kussy,Keelin M Greenlaw,ChangJiang Xu,Nicholas C. Harvey,Nicholas C. Harvey,Cyrus Cooper,Cyrus Cooper,Cyrus Cooper,David J. Adams,Celia M. T. Greenwood,Matthew T. Maurano,Stephen Kaptoge,Fernando Rivadeneira,Jonathan H Tobias,Peter I. Croucher,Peter I. Croucher,Cheryl L. Ackert-Bicknell,J. H. Duncan Bassett,Graham R. Williams,J. Brent Richards,J. Brent Richards,David M. Evans,David M. Evans +46 more
TL;DR: The results implicate GPC6 as a novel determinant of BMD, and also identify abnormal skeletal phenotypes in knockout mice associated with a further 100 prioritized genes.
Journal ArticleDOI
Estrogen maintains trabecular bone volume in rats not only by suppression of bone resorption but also by stimulation of bone formation.
TL;DR: It appears that estrogen maintains bone volume not only through inhibition of bone resorption, but also through stimulation of bone formation, which masks a simultaneous reduction in estrogen-dependent bone formation.