J
Jielin Sun
Researcher at Wake Forest University
Publications - 117
Citations - 8084
Jielin Sun is an academic researcher from Wake Forest University. The author has contributed to research in topics: Prostate cancer & Single-nucleotide polymorphism. The author has an hindex of 48, co-authored 115 publications receiving 7689 citations. Previous affiliations of Jielin Sun include Fudan University.
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Journal ArticleDOI
Genome-wide association study identifies a second prostate cancer susceptibility variant at 8q24.
Julius Gudmundsson,Patrick Sulem,Andrei Manolescu,Laufey T. Amundadottir,Daniel F. Gudbjartsson,Agnar Helgason,Thorunn Rafnar,Jon Thor Bergthorsson,Bjarni A. Agnarsson,Adam Baker,Asgeir Sigurdsson,Kristrun R. Benediktsdottir,Margret Jakobsdottir,Jianfeng Xu,Thorarinn Blondal,Jelena Kostic,Jielin Sun,Shyamali Ghosh,Simon N. Stacey,Magali Mouy,Jona Saemundsdottir,Valgerdur M Backman,Kristleifur Kristjansson,Alejandro Tres,Alan W. Partin,Marjo T Albers-Akkers,Javier Godino-Ivan Marcos,Patrick C. Walsh,Dorine W. Swinkels,Sebastian Navarrete,Sarah D. Isaacs,Katja K.H. Aben,Theresa Graif,John Cashy,M. Ruiz-Echarri,Kathleen E. Wiley,Brian K. Suarez,J. Alfred Witjes,Mike Frigge,Carole Ober,Eirikur Jonsson,Gudmundur V. Einarsson,Jose I. Mayordomo,Lambertus A. Kiemeney,William B. Isaacs,William J. Catalona,Rosa B. Barkardottir,Jeffrey R. Gulcher,Unnur Thorsteinsdottir,Augustine Kong,Kari Stefansson +50 more
TL;DR: A second genetic variant in the 8q24 region that, in conjunction with another variant recently discovered, accounts for about 11%–13% of prostate cancer cases in individuals of European descent and 31% of cases in African Americans is reported.
Journal ArticleDOI
Cumulative Association of Five Genetic Variants with Prostate Cancer
S. Lilly Zheng,Jielin Sun,Fredrik Wiklund,Shelly G. Smith,Pär Stattin,Ge Li,Hans-Olov Adami,Hans-Olov Adami,Fang-Chi Hsu,Yi Zhu,Katarina Bälter,A. Karim Kader,Aubrey R. Turner,Wennuan Liu,Eugene R. Bleecker,Deborah A. Meyers,David Duggan,John D. Carpten,Bao Li Chang,William B. Isaacs,Jianfeng Xu,Henrik Grönberg +21 more
TL;DR: In this paper, single-nucleotide polymorphisms (SNPs) in five chromosomal regions were associated with prostate cancer in a Swedish population, three at 8q24 and one each at 17q12 and 17q24.
Journal ArticleDOI
Common sequence variants on 2p15 and Xp11.22 confer susceptibility to prostate cancer
Julius Gudmundsson,Patrick Sulem,Thorunn Rafnar,Jon Thor Bergthorsson,Andrei Manolescu,Daniel F. Gudbjartsson,Bjarni A. Agnarsson,Asgeir Sigurdsson,Kristrun R. Benediktsdottir,Thorarinn Blondal,Margret Jakobsdottir,Simon N. Stacey,Jelena Kostic,Kari T. Kristinsson,Birgitta Birgisdottir,Shyamali Ghosh,Droplaug N Magnusdottir,Steinunn Thorlacius,Gudmar Thorleifsson,S. Lilly Zheng,Jielin Sun,Bao Li Chang,J. Bradford Elmore,Joan P. Breyer,Kate M. McReynolds,Kevin M. Bradley,Brian L. Yaspan,Fredrik Wiklund,Pär Stattin,Sara Lindström,Hans-Olov Adami,Hans-Olov Adami,Shannon K. McDonnell,Daniel J. Schaid,Julie M. Cunningham,Liang Wang,James R. Cerhan,Jennifer L. St. Sauver,Sara D. Isaacs,Kathleen E. Wiley,Alan W. Partin,Patrick C. Walsh,Sonia Polo,M. Ruiz-Echarri,Sebastian Navarrete,Fernando Fuertes,Berta Saez,Javier Godino,Philip C. Weijerman,Dorine W. Swinkels,Katja K.H. Aben,J. Alfred Witjes,Brian K. Suarez,Brian T. Helfand,Michael L. Frigge,Kristleifur Kristjansson,Carole Ober,Eirikur Jonsson,Gudmundur V. Einarsson,Jianfeng Xu,Henrik Grönberg,Jeffrey R. Smith,Jeffrey R. Smith,Stephen N. Thibodeau,William B. Isaacs,William J. Catalona,Jose I. Mayordomo,Lambertus A. Kiemeney,Rosa B. Barkardottir,Jeffrey R. Gulcher,Unnur Thorsteinsdottir,Augustine Kong,Kari Stefansson +72 more
TL;DR: The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.
Journal ArticleDOI
Two Genome-wide Association Studies of Aggressive Prostate Cancer Implicate Putative Prostate Tumor Suppressor Gene DAB2IP
David Duggan,Siqun L. Zheng,Michele Knowlton,Debbie S. Benitez,Latchezar Dimitrov,Fredrik Wiklund,Christiane M. Robbins,Sarah D. Isaacs,Yu Cheng,Ge Li,Jielin Sun,Bao Li Chang,Leslie Marovich,Kathleen E. Wiley,Katarina Bälter,Pär Stattin,Hans-Olov Adami,Hans-Olov Adami,Marta Gielzak,Guifang Yan,Jurga Sauvageot,Wennuan Liu,Jin Woo Kim,Eugene R. Bleecker,Deborah A. Meyers,Bruce J. Trock,Alan W. Partin,Patrick C. Walsh,William B. Isaacs,Henrik Grönberg,Jianfeng Xu,John D. Carpten +31 more
TL;DR: A genetic variant in DAB2IP gene, which encodes a novel Ras GTPase-activating protein and putative prostate tumor suppressor, may be associated with the risk of aggressive prostate cancer and should be evaluated further.
Journal ArticleDOI
Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma
De Ke Jiang,Jielin Sun,Guangwen Cao,Yao Liu,Dongxin Lin,Yu Zhen Gao,Wei Hua Ren,Wei Hua Ren,Xi Dai Long,Hongxing Zhang,Xiao Pin Ma,Zhong Wang,Wei Jiang,Tao Yang Chen,Yong Gao,Yong Gao,Liangdan Sun,Jirong Long,Hui Xing Huang,Dan Wang,Hongjie Yu,Pengyin Zhang,Li Sha Tang,Bo Peng,Hao Cai,Ting Ting Liu,Ping Zhou,Fang Liu,Xiaoling Lin,Sha Tao,Bo Wan,He Xi Ge Sai-Yin,Lun Xiu Qin,Jianhua Yin,Li Liu,Chen Wu,Yan Pei,Yuan Feng Zhou,Yun Zhai,Pei Xin Lu,Aihua Tan,Xian Bo Zuo,Jia Fan,Jiang Chang,Xiaoli Gu,Neng Jin Wang,Yang Li,Yin Kun Liu,Kan Zhai,Hongwei Zhang,Zhibin Hu,Jun Liu,Jun Liu,Qing Yi,Yong-Bing Xiang,Rong Shi,Qiang Ding,Wei Zheng,Xiao-Ou Shu,Zengnan Mo,Yin Yao Shugart,Xuejun Zhang,Gangqiao Zhou,Hongbing Shen,S. Lilly Zheng,Jianfeng Xu,Jianfeng Xu,Long Yu +67 more
TL;DR: To identify genetic susceptibility loci for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in the Chinese population, a genome-wide association study in 2,514 chronic HBV carriers followed by a 2-stage validation among 6 independent populations of chronicHBV carriers showed that HCC risk was significantly associated with two independent loci.