Fernando Fuertes

TL;DR: Results from eight case-control groups demonstrate that this variant in TCF2 (HNF1β), a gene known to be mutated in individuals with maturity-onset diabetes of the young type 5, confers protection against type 2 diabetes.

TL;DR: The 2p15 variant shows a significantly stronger association with more aggressive, rather than less aggressive, forms of the disease.

TL;DR: In a multivariate analysis using 22 prostate cancer risk variants typed in the Icelandic population, it is estimated that carriers in the top 1.3% of the risk distribution are at a 2.5 times greater risk of developing the disease than members of the general population.

TL;DR: A genome-wide association study of 16 million SNPs identified through whole-genome sequencing of 457 Icelanders found that rs78378222 is in the 3′ untranslated region of TP53 and changes the AATAAA polyadenylation signal to AATACA, resulting in impaired 3′-end processing of TP 53 mRNA.

TL;DR: A new low-frequency variant at 8q24 associated with prostate cancer in European populations, rs188140481[A] is identified and its association remains significant after adjustment for all known risk-associated variants.