J
Joanne M. Meyer
Researcher at Novartis
Publications - 108
Citations - 14020
Joanne M. Meyer is an academic researcher from Novartis. The author has contributed to research in topics: Twin study & Population. The author has an hindex of 53, co-authored 108 publications receiving 13590 citations. Previous affiliations of Joanne M. Meyer include Millennium Pharmaceuticals & VCU Medical Center.
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Journal ArticleDOI
Genome-Wide Association Analysis Identifies Loci for Type 2 Diabetes and Triglyceride Levels
Richa Saxena,Benjamin F. Voight,Valeriya Lyssenko,Noël P. Burtt,Paul I.W. de Bakker,Hong Chen,Jeffrey J. Roix,Sekar Kathiresan,Joel N. Hirschhorn,Mark J. Daly,Thomas E. Hughes,Leif Groop,David Altshuler,Peter Almgren,Jose C. Florez,Joanne M. Meyer,Kristin Ardlie,Kristina Bengtsson Boström,Bo Isomaa,Guillaume Lettre,Ulf Lindblad,Helen N. Lyon,Olle Melander,Christopher Newton-Cheh,Peter Nilsson,Marju Orho-Melander,Lennart Råstam,Elizabeth K. Speliotes,Marja-Riitta Taskinen,Tiinamaija Tuomi,Candace Guiducci,Anna Berglund,Joyce Carlson,Lauren Gianniny,Rachel Hackett,Liselotte Hall,Johan Holmkvist,Esa Laurila,Marketa Sjögren,Maria Sterner,Aarti Surti,Margareta Svensson,Malin Svensson,Ryan Tewhey,Brendan Blumenstiel,Melissa Parkin,Matthew DeFelice,Rachel Barry,Wendy Brodeur,Jody Camarata,Nancy Chia,Mary Fava,John G. Gibbons,Bob Handsaker,Claire M. Healy,Kieu Nguyen,Casey Gates,Carrie Sougnez,Diane Gage,Marcia M. Nizzari,Stacey Gabriel,Gung-Wei Chirn,Qicheng Ma,Hemang Parikh,Delwood Richardson,Darrell O. Ricke,Shaun Purcell +66 more
TL;DR: The discovery of associated variants in unsuspected genes and outside coding regions illustrates the ability of genome-wide association studies to provide potentially important clues to the pathogenesis of common diseases.
Journal ArticleDOI
Co-occurrence of Abuse of Different Drugs in Men The Role of Drug-Specific and Shared Vulnerabilities
Ming T. Tsuang,Michael J. Lyons,Joanne M. Meyer,Thomas Doyle,Seth A. Eisen,Jack Goldberg,William R. True,Nong Lin,Rosemary Toomey,Lindon J. Eaves +9 more
TL;DR: Evidence is found for a shared or common vulnerability factor that underlies the abuse of marijuana, sedatives, stimulants, heroin or opiates, and psychedelics that is influenced by genetic, family environmental, and nonfamily environmental factors.
Journal ArticleDOI
Epigenetic Modification of the FMR1 Gene in Fragile X Syndrome Is Associated with Differential Response to the mGluR5 Antagonist AFQ056
Sébastien Jacquemont,Aurore Curie,Vincent des Portes,Maria Giulia Torrioli,Elizabeth Berry-Kravis,Randi J Hagerman,Feliciano J. Ramos,Kim Cornish,Yunsheng He,Charles Paulding,Giovanni Neri,Fei Chen,Fei Chen,Nouchine Hadjikhani,Nouchine Hadjikhani,Danielle Martinet,Joanne M. Meyer,Jacques S. Beckmann,Karine Delange,Amandine Brun,Gérald Bussy,Fabrizio Gasparini,Talita Hilse,Annette Floesser,Janice Branson,Graeme Bilbe,Donald Johns,Baltazar Gomez-Mancilla +27 more
TL;DR: An antagonist for the metabotropic glutamate receptor may improve symptoms in patients with fragile X syndrome whose FMR1 promoters are fully methylated, a sign that gene expression is completely silenced, and provides the basis for a larger study to test whether methylation can serve as a predictor of a positive antagonist response in a population of patients with Fragile X syndrome.
Journal ArticleDOI
The path to personalized medicine.
TL;DR: Research is leading to the identification of a range of molecular markers for predisposition testing, disease screening and prognostic assessment, as well as markers used to predict and monitor drug response.
Journal ArticleDOI
Genetics and Developmental Psychopathology: 2. The Main Effects of Genes and Environment on Behavioral Problems in the Virginia Twin Study of Adolescent Behavioral Development
Lindon J. Eaves,Judy L. Silberg,Joanne M. Meyer,Hermine H. Maes,Emily Simonoff,Andrew Pickles,Michael Rutter,Chandra A. Reynolds,Andrew C. Heath,Kimberly R. Truett,Michael C. Neale,Marilyn T. Erikson,Rolf Loeber,John K. Hewitt +13 more
TL;DR: A widespread influence of genetic factors on risk to adolescent psychopathology is supported and suggests that the contribution of different types of social influence may vary consistently across domains of measurement.