J
Joerg Huelsken
Researcher at École Polytechnique Fédérale de Lausanne
Publications - 69
Citations - 11179
Joerg Huelsken is an academic researcher from École Polytechnique Fédérale de Lausanne. The author has contributed to research in topics: Stem cell & Wnt signaling pathway. The author has an hindex of 36, co-authored 63 publications receiving 9715 citations. Previous affiliations of Joerg Huelsken include ISREC & University of Seville.
Papers
More filters
Journal ArticleDOI
beta-Catenin controls hair follicle morphogenesis and stem cell differentiation in the skin.
TL;DR: It is shown that beta-catenin is required genetically downstream of tabby/downless and upstream of bmp and shh in placode formation and is essential for fate decisions of skin stem cells: in the absence of beta-Catenin, stem cells fail to differentiate into follicular keratinocytes, but instead adopt an epidermal fate.
Journal ArticleDOI
Interactions between cancer stem cells and their niche govern metastatic colonization
Ilaria Malanchi,Albert Santamaria-Martínez,Evelyn Susanto,Hong Peng,Hong Peng,Hans-Anton Lehr,Jean-François Delaloye,Joerg Huelsken +7 more
TL;DR: It is suggested that the education of stromal cells by infiltrating tumour cells is an important step in metastatic colonization and that preventing de novo niche formation may be a novel strategy for the treatment of metastatic disease.
Journal ArticleDOI
Machine Learning Identifies Stemness Features Associated with Oncogenic Dedifferentiation
Tathiane M. Malta,Artem Sokolov,Andrew J. Gentles,Tomasz Burzykowski,Laila M. Poisson,John N. Weinstein,Bozena Kaminska,Joerg Huelsken,Larsson Omberg,Olivier Gevaert,Antonio Colaprico,Patrycja Czerwińska,Sylwia Mazurek,Lopa Mishra,Holger Heyn,Alexander Krasnitz,Andrew K. Godwin,Alexander J. Lazar,Joshua M. Stuart,Katherine A Hoadley,Peter W. Laird,Houtan Noushmehr,Maciej Wiznerowicz +22 more
TL;DR: Novel stemness indices for assessing the degree of oncogenic dedifferentiation are provided and it is found that the dedifferentiated oncogenic phenotype was generally most prominent in metastatic tumors.
Journal ArticleDOI
Requirement for beta-catenin in anterior-posterior axis formation in mice.
Joerg Huelsken,Regina Vogel,Volker Brinkmann,Bettina Erdmann,Carmen Birchmeier,Walter Birchmeier +5 more
TL;DR: The data demonstrate that β-catenin function is essential in anterior-posterior axis formation in the mouse, and experiments with chimeric embryos show that this function is required in the embryonic ectoderm.
Journal ArticleDOI
Cutaneous cancer stem cell maintenance is dependent on beta-catenin signalling.
Ilaria Malanchi,Héctor Peinado,Deepika Kassen,Thomas Hussenet,Daniel Metzger,Pierre Chambon,Marcel Huber,Daniel Hohl,Amparo Cano,Walter Birchmeier,Joerg Huelsken +10 more
TL;DR: A population of cells in early epidermal tumours characterized by phenotypic and functional similarities to normal bulge skin stem cells is identified and β-catenin signalling is described as being essential in sustaining the CSC phenotype.