Battista Fabio Viola

TL;DR: Three independent loci in the major histocompatibility complex, as well as a common deletion of CFHR1 and CFHR3 at chromosome 1q32 and a locus at chromosome 22q12 that each surpassed genome-wide significance, explain 4–7% of the disease variance and up to a tenfold variation in interindividual risk.

TL;DR: A genome-wide association study of IgA nephropathy (IgAN), the most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of European and East Asian ancestry is performed, suggesting a possible role for host–intestinal pathogen interactions in shaping the genetic landscape of IgAN.

TL;DR: By genome-wide analysis of linkage in 30 multiplex IgAN kindreds, this work demonstrates linkage of IgAN to 6q22–23 under a dominant model of transmission with incomplete penetrance and indicates the existence of a locus with large effect on development of IgA nephropathy.

TL;DR: Renal atheroembolic disease is a difficult and controversial diagnosis for the protean extrarenal manifestations of the disease, and recent data suggest that an aggressive therapeutic approach with patient-tailored supportive measures may be associated with a favorable clinical outcome.

TL;DR: An sVLPD was effective and safe when postponing dialysis treatment in elderly patients without diabetes in 1-year mortality assessed by using intention-to-treat and per-protocol analysis.