R
Robert J. Wyatt
Researcher at University of Tennessee
Publications - 164
Citations - 10639
Robert J. Wyatt is an academic researcher from University of Tennessee. The author has contributed to research in topics: Nephropathy & Glomerulonephritis. The author has an hindex of 51, co-authored 162 publications receiving 9418 citations. Previous affiliations of Robert J. Wyatt include University of Alabama at Birmingham & University of Bari.
Papers
More filters
Journal ArticleDOI
Oxford Classification of IgA nephropathy 2016: an update from the IgA Nephropathy Classification Working Group
Hernán Trimarchi,Jonathan Barratt,Daniel C. Cattran,H. Terence Cook,Rosanna Coppo,Mark Haas,Zhihong Liu,Ian S.D. Roberts,Yukio Yuzawa,Hong Zhang,John Feehally,Charles E. Alpers,Ana María Asunis,Sean J. Barbour,Jan U. Becker,Jie Ding,Gabriella Espino,Franco Ferrario,Agnes B. Fogo,Michelle Hladunewich,Kensuke Joh,Ritsuko Katafuchi,Jicheng Lv,Keiichi Matsuzaki,Koichi Nakanishi,Antonello Pani,Ran Perera,Agnieszka Perkowska-Ptasińska,Heather N. Reich,Yuko Shima,Maria Fernanda Soares,Yusuke Suzuki,Katsuo Takahashi,Stéphan Troyanov,Jacobien C. Verhave,Suxia Wang,Jan J. Weening,Robert J. Wyatt,N Yoshikawa,Caihong Zeng +39 more
TL;DR: It has now been shown that combining the MEST score with clinical data at biopsy provides the same predictive power as monitoring clinical data for 2 years; this requires further evaluation to assess earlier effective treatment intervention.
Journal ArticleDOI
The Pathophysiology of IgA Nephropathy
Hitoshi Suzuki,Krzysztof Kiryluk,Jan Novak,Zina Moldoveanu,Andrew B. Herr,Matthew B. Renfrow,Robert J. Wyatt,Francesco Scolari,Jiri Mestecky,Ali G. Gharavi,Bruce A. Julian +10 more
TL;DR: Recent advances in understanding the biochemical, immunologic, and genetic pathogenesis of IgA nephropathy are discussed, and five distinct susceptibility loci are identified that potentially influence these processes and contain candidate mediators of disease.
Journal ArticleDOI
Genome-wide association study identifies susceptibility loci for IgA nephropathy
Ali G. Gharavi,Krzysztof Kiryluk,Murim Choi,Yifu Li,Ping Hou,Ping Hou,Jingyuan Xie,Jingyuan Xie,Simone Sanna-Cherchi,Clara J. Men,Bruce A. Julian,Robert J. Wyatt,Jan Novak,John Cijiang He,Haiyan Wang,Jicheng Lv,Li Zhu,Weiming Wang,Zhaohui Wang,Kasuhito Yasuno,Murat Gunel,Shrikant Mane,Sheila Umlauf,Irina Tikhonova,Isabel Beerman,Silvana Savoldi,Riccardo Magistroni,Gian Marco Ghiggeri,Monica Bodria,Francesca Lugani,Francesca Lugani,Pietro Ravani,Claudio Ponticelli,Landino Allegri,Giuliano Boscutti,Giovanni M. Frascà,Alessandro Amore,Licia Peruzzi,Rosanna Coppo,Claudia Izzi,Battista Fabio Viola,Prati E,Maurizio Salvadori,Renzo Mignani,Loreto Gesualdo,Francesca Bertinetto,Paola Mesiano,Antonio Amoroso,Francesco Scolari,Nan Chen,Hong Zhang,Richard P. Lifton +51 more
TL;DR: Three independent loci in the major histocompatibility complex, as well as a common deletion of CFHR1 and CFHR3 at chromosome 1q32 and a locus at chromosome 22q12 that each surpassed genome-wide significance, explain 4–7% of the disease variance and up to a tenfold variation in interindividual risk.
Journal ArticleDOI
Discovery of new risk loci for IgA nephropathy implicates genes involved in immunity against intestinal pathogens
Krzysztof Kiryluk,Yifu Li,Francesco Scolari,Simone Sanna-Cherchi,Murim Choi,Miguel Verbitsky,David Fasel,Sneh Lata,Sindhuri Prakash,Samantha Shapiro,Clara Fischman,Holly J. Snyder,Gerald B. Appel,Claudia Izzi,Battista Fabio Viola,Nadia Dallera,Lucia Del Vecchio,Cristina Barlassina,Erika Salvi,Francesca Bertinetto,Antonio Amoroso,Silvana Savoldi,Marcella Rocchietti,Alessandro Amore,Licia Peruzzi,Rosanna Coppo,Maurizio Salvadori,Pietro Ravani,Riccardo Magistroni,Gian Marco Ghiggeri,Gianluca Caridi,Monica Bodria,Francesca Lugani,Landino Allegri,Marco Delsante,Mariarosa Maiorana,Andrea Magnano,Giovanni M. Frascà,Emanuela Boer,Giuliano Boscutti,Claudio Ponticelli,Renzo Mignani,Carmelita Marcantoni,Domenico Di Landro,Domenico Santoro,Antonello Pani,Rosaria Polci,Sandro Feriozzi,Silvana Chicca,Marco Galliani,Maddalena Gigante,Loreto Gesualdo,Pasquale Zamboli,Giovanni Giorgio Battaglia,Maurizio Garozzo,Dita Maixnerova,Vladimir Tesar,Frank Eitner,Thomas Rauen,Jürgen Floege,Tibor Kovács,Judit Nagy,Krzysztof Mucha,Leszek Pączek,Marcin Zaniew,Małgorzata Mizerska-Wasiak,Maria Roszkowska-Blaim,Krzysztof Pawlaczyk,Daniel P. Gale,Jonathan Barratt,Lise Thibaudin,François Berthoux,Guillaume Canaud,Anne Boland,Marie Metzger,Ulf Panzer,Hitoshi Suzuki,Shin Goto,Ichiei Narita,Yasar Caliskan,Jingyuan Xie,Ping Hou,Nan Chen,Hong Zhang,Robert J. Wyatt,Jan Novak,Bruce A. Julian,John Feehally,Bénédicte Stengel,Daniele Cusi,Richard P. Lifton,Ali G. Gharavi +91 more
TL;DR: A genome-wide association study of IgA nephropathy (IgAN), the most common form of glomerulonephritis, with discovery and follow-up in 20,612 individuals of European and East Asian ancestry is performed, suggesting a possible role for host–intestinal pathogen interactions in shaping the genetic landscape of IgAN.
Journal ArticleDOI
Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity
Hitoshi Suzuki,Run Fan,Zhixin Zhang,Rhubell Brown,Stacy Hall,Bruce A. Julian,W. Winn Chatham,Yusuke Suzuki,Robert J. Wyatt,Zina Moldoveanu,Jeannette Y. Lee,James E. Robinson,Milan Tomana,Yasuhiko Tomino,Jiri Mestecky,Jan Novak +15 more
TL;DR: Findings indicate that glycan-specific antibodies are associated with the development of IgAN and may represent a disease-specific marker and potential therapeutic target.