J
Jorge Azpurua
Researcher at Stony Brook University
Publications - 21
Citations - 2219
Jorge Azpurua is an academic researcher from Stony Brook University. The author has contributed to research in topics: Naked mole-rat & Contact inhibition. The author has an hindex of 14, co-authored 21 publications receiving 1935 citations. Previous affiliations of Jorge Azpurua include University of Rochester & University of Texas at Austin.
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Journal ArticleDOI
High-molecular-mass hyaluronan mediates the cancer resistance of the naked mole rat
Xiao Tian,Jorge Azpurua,Christopher Hine,Christopher Hine,Amita M. Vaidya,Max Myakishev-Rempel,Julia Ablaeva,Zhiyong Mao,Zhiyong Mao,Eviatar Nevo,Vera Gorbunova,Andrei Seluanov +11 more
TL;DR: It is speculated that naked mole rats have evolved a higher concentration of HA in the skin to provide skin elasticity needed for life in underground tunnels and this trait may have then been co-opted to provide cancer resistance and longevity to this species.
Journal ArticleDOI
Corrigendum: Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax.
Xiaodong Fang,Eviatar Nevo,Lijuan Han,Erez Y. Levanon,Jing Zhao,Aaron Avivi,Denis M. Larkin,Xuanting Jiang,Sergey Feranchuk,Yabing Zhu,Alla Fishman,Yue Feng,Noa Sher,Zhiqiang Xiong,Thomas Hankeln,Zhiyong Huang,Vera Gorbunova,Lu Zhang,Wei Zhao,Derek E. Wildman,Derek E. Wildman,Yingqi Xiong,Andrei V. Gudkov,Qiumei Zheng,Gideon Rechavi,Sanyang Liu,Lily Bazak,Jie Chen,Jie Chen,Binyamin A. Knisbacher,Yao Lu,Imad Shams,Krzysztof Gajda,Marta Farré,Jaebum Kim,Harris A. Lewin,Jian Ma,Mark Band,Anne Bicker,Angela Kranz,Tobias Mattheus,Hanno Schmidt,Andrei Seluanov,Jorge Azpurua,Michael R. McGowen,Eshel Ben Jacob,Kexin Li,Shaoliang Peng,Xiaoqian Zhu,Xiangke Liao,Shuai Cheng Li,Anders Krogh,Xin Zhou,Leonid Brodsky,Jun Wang +54 more
TL;DR: In this paper, a Genome-Wide Adaptive Complex to underground stresses in blind mole rats Spalax is described, where the adaptive complexes are based on adaptive complexes to underground stress.
Journal ArticleDOI
Hypersensitivity to contact inhibition provides a clue to cancer resistance of naked mole-rat
Andrei Seluanov,Christopher Hine,Jorge Azpurua,Marina Feigenson,Michael J. Bozzella,Zhiyong Mao,Kenneth C. Catania,Vera Gorbunova +7 more
TL;DR: In this article, it was shown that naked mole-rat fibroblasts display hypersensitivity to contact inhibition, a phenomenon termed "early contact inhibition", and the roles of p16Ink4a and p27Kip1 in the control of contact inhibition became temporally separated in this species.
Journal ArticleDOI
Genome-wide adaptive complexes to underground stresses in blind mole rats Spalax
Xiaodong Fang,Eviatar Nevo,Lijuan Han,Erez Y. Levanon,Jing Zhao,Aaron Avivi,Denis M. Larkin,Xuanting Jiang,Sergey Feranchuk,Yabing Zhu,Alla Fishman,Yue Feng,Noa Sher,Zhiqiang Xiong,Thomas Hankeln,Zhiyong Huang,Vera Gorbunova,Lu Zhang,Wei Zhao,Derek E. Wildman,Yingqi Xiong,Andrei V. Gudkov,Qiumei Zheng,Gideon Rechavi,Sanyang Liu,Lily Bazak,Jie Chen,Binyamin A. Knisbacher,Yao Lu,Imad Shams,Krzysztof Gajda,Marta Farré,Jaebum Kim,Harris A. Lewin,Jian Ma,Mark Band,Anne Bicker,Angela Kranz,Tobias Mattheus,Hanno Schmidt,Andrei Seluanov,Jorge Azpurua,Michael R. McGowen,Eshel Ben Jacob,Kexin Li,Shaoliang Peng,Xiaoqian Zhu,Xiangke Liao,Shuai Cheng Li,Anders Krogh,Xin Zhou,Leonid Brodsky,Jun Wang,Jun Wang +53 more
TL;DR: The results show high rates of RNA/DNA editing, reduced chromosome rearrangements, an over-representation of short interspersed elements (SINEs) probably linked to Hypoxia tolerance, degeneration of vision and progression of photoperiodic perception, tolerance to hypercapnia and hypoxia and resistance to cancer.
Journal ArticleDOI
Naked mole-rat has increased translational fidelity compared with the mouse, as well as a unique 28S ribosomal RNA cleavage.
Jorge Azpurua,Zhonghe Ke,Iris X. Chen,Quanwei Zhang,Dmitri N. Ermolenko,Zhengdong D. Zhang,Vera Gorbunova,Andrei Seluanov +7 more
TL;DR: The results show that naked mole-rat cells produce fewer aberrant proteins, supporting the hypothesis that the more stable proteome of the naked Mole-rat contributes to its longevity.